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SAC & Infectious Diseases

By April 15, 2020Resources, SAC

SAC Therapy and Infectious Diseases

Creating an Adverse Environment for Pathogen Survival & Simultaneously Boosting the Immune Response

SAC in a
Nutshell

SAC (Sigma Antibonding Calcium Carbonate) is the only true ionic calcium delivery system that provides calcium in a free ionic state, which is the only physiologically active form of calcium in our body. Normally, calcium from diet and supplements enters our body in the protein-bound form and, therefore, cannot trigger the same physiological responses as SAC. Resolving calcium deficiency better than protein-bound calcium, SAC triggers ionic-calcium-sensitive physiological responses that counteract the root cause of diseases and brings natural healing reactions of our body from cellular to the systemic level.

What Are Infectious Diseases?

Infectious diseases are disorders caused by organisms — such as bacteria, viruses, fungi or parasites. Many organisms live in and on our bodies. They’re normally harmless or even helpful. But under certain conditions, some organisms may cause disease.

Some infectious diseases can be passed from person to person. Some are transmitted by insects or other animals. And you may get others by consuming contaminated food or water or being exposed to organisms in the environment.

Signs and symptoms vary depending on the organism causing the infection, but often include fever and fatigue. Mild infections may respond to rest and home remedies, while some life-threatening infections may need hospitalization.

Understanding Viral Infection

Virus originates from RNAs. The ribose sugar in RNA is phosphates based and reacts in the nucleotides to form an ester bond. While not inside a cell or in the process of cell infection, the virus exists as an independent particle known as virions or virus particles. The way the virus replicates depends on the presence of phosphates in the form of copolymerization with ribose and nucleus. The virus cannot produce energy for metabolism nor synthesize protein. Hence, to replicate, the virus forms the capsid, a protective protein shell, using pre-existing proteins in an infected cell.  Knowing the mechanics and the nature of viral proliferation, SAC Therapy may hold the key for the most complete antiviral strategy. 

Using Calcium as an Antiviral Strategy by Optimizing Energy Production

The virus travels in the body via extracellular fluid for replication. Since the viral replication requires a particular environment with an adequate supply of phosphates and the surrounding temperature lower than 36 °C, the above condition should be avoided at all costs if one wants to prevent virus infection and replication. One can keep viral infection at bay by increasing the level of plasma ionized calcium, which plays a significant role in glucose metabolism and redox reaction, which raises the body temperature and deactivates active RNA from multiplying.

Calcium injection was used as a medicinal treatment for patients with the common cold in the 18th century with some success.  Such practice did not last long due to calcium’s affinity to proteins that could lead to the formation of calcium deposits in the blood vessel. Nevertheless, the beneficial effect of calcium in the prevention of viral activity has always been acknowledged and recognized. With SAC Ionic Calcium Therapy, benefits of calcium is maximized without any side effects. 

Ionic Calcium Inactivates Viral RNA

SAC increases fluid ionized calcium levels in plasma, intracellular and extracellular spaces, which forms a complex with phosphates to deactivate RNA. (Figure 1)  SAC is capable of providing 1.25 x 1019 ionic calcium readily into the blood plasma and cellular matrix.  In severe viral infection cases, it is recommended to take SAC every three hours to maintain elevated ionic calcium level for continued deactivation of viral RNA.

In patient trials with HIV, maintaining adequate amount of ionic calcium helped lower the viral load to practical non-existance.  Although we have monitored the beneficial effect of SAC on HIV via case studies, we are uncertain whether HIV is completely eradicated or remains inactive due to the obnoxiously long silence period of HIV.

Figure 1. inactivation of viral RNA by ionized calcium.

Ionic Calcium Multiplies Eosinophils against Virus

Eosinophils are a type of disease-fighting white blood cell. You can have high levels of eosinophils in your blood (blood eosinophilia) or in tissues at the site of an infection or inflammation (tissue eosinophilia).

Eosinophil is one type of white blood cell that is known to play a role in the immune system against infections. In parallel with the role of calcium in the prevention of viral infection via inactivation of virus RNA, eosinophils also contain RNases that are capable of degrading RNA into smaller components and thus inactivating viral infection [1]. Moreover, eosinophils attenuate viral activity through the production of nitric oxide [1]. According to a study conducted by Choi et al., when water containing 0.0012% SAC was administered for 12 weeks, rats showed significantly increased concentration of eosinophils compared to that of control rats, suggesting the beneficial effect of SAC against viral infection which could be mediated via increased eosinophil activity [2]. 

REFERENCES

  1. Drake, M.G., et al., Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus. Am J Respir Cell Mol Biol, 2016. 55(3): p. 387-94.
  2. Choi, S.Y., et al., Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats. Lab Anim Res, 2011. 27(4): p. 301-7.

RESEARCH: Eosinophils Interactions with Virus

“However, experiments carried out in vitro and in vivo suggest positive roles for eosinophils, as they have been shown to reduce virus infectivity in tissue culture and promote clearance of the human pathogen, respiratory syncytial virus (RSV) in a mouse challenge model.”

“When eosinophils were added in increasing concentration to a fixed number of viruses, dose-dependent inhibition of virus infectivity was observed

“Thus, not only is this another clear demonstration of antiviral effects of mouse eosinophils in vivo, but the first suggestion of a role for TLRs – specifically TLR7, in promoting eosinophil-mediated antiviral activity”

Immunol Res. 2009 ; 43(1-3): 128–137. doi:10.1007/s12026-008-8058-5

“Eosinophils recruited to the airways of wild-type mice after ovalbumin sensitization and challenge significantly decreased parainfluenza virus RNA in the lungs 4 days after infection compared with nonsensitized animals.”

“Eosinophil antiviral mechanisms were also explored in vitro. Isolated human eosinophils significantly reduced parainfluenza virus titers.”

Clinical Relevance

“Human and mouse eosinophils are antiviral against parainfluenza virus via the production of nitric oxide and by serving as a dead-end host for virus infection, but not through the production of eosinophil granule RNases or  eosinophil peroxidase. Eosinophils may have an underappreciated antiviral role in respiratory tract infections in humans.”

Drake, Bivins-Smith, Proskocil, et al.: Antiviral Effects of Eosinophils

RESEARCH: Increase of Eosinophils under SAC Therapy

“Hematological values of ovariectomized rat treated with SAC for 12 weeks have revealed a statistically significant increase in eosinophils in the SAC treated group after ovariectomy, although there was a big deviation (Table 4).

There were no significant changes in the blood parameters related to the hepatotoxicity (AST, ALT and ALP), hepatic energy storage and pancreatic injury (glucose), hepatic lipid metabolism (trigltcerides, total cholesterol, DHL and LDL), hepatic protein synthesis (total proteins and albumin), renal injury and electrolyte balance (BUN, calcium and phosphorus). Especially, however, ALP, a bone growth marker, increased moderately in SAC-treated animals.”

Lab Anim Res 2011: 27(4), 301-307

RESEARCH: Ca2+ Boosts the Killing Efficiency of CTL & NK Cells

“Killing pathogens by cytotoxic T-lymphocytes (CTL) and by natural killer (NK) cells is of vital importance. In one cancer study, cancer cell proliferation and apoptosis depend on the intracellular Ca2+ concentration, and the expression of numerous ion channels with the ability to control intracellular Ca2+ concentrations has been correlated with cancer.  This study found that a rise of intracellular Ca2+ concentrations is also required for efficient CTL and NK cell function and thus for killing their targets. (cancer cells and pathogens alike) This study discusses emerging ideas and present a model how Ca2+ may be used by CTL and NK cells to optimize their killing efficiency. This article is part of a Special Issue entitled: 12th European Symposium on Calcium.”

Highlights

► Cytotoxic T lymphocyte (CTL) and natural killer (NK) cells kill cancer cells. ► Calcium modulates killing of cancer cells by CTL and NK cells. ► Several steps of the actual killing process are calcium dependent. ► A model is discussed how calcium influences the cancer-immune interaction.

Biochimica et Biophysica Acta 1833 (2013) 16031611

SAC Regulate Body pH for Strengthening Immune Response and Stopping Viral Proliferation

Ideal pH is for Ideal Immune Response

Research shows that polymorphonuclear neutrophils demonstrate mainly inhibition of chemotaxis, respiratory activity, and bactericidal capacity in an acidic environment. Chemotaxis is a part of the inflammatory response, where white blood cells react to invading pathogens along a chemical concentration gradient. Extracellular pH changes influence the intracellular pH of white blood cells, which ultimately influences the process of cell death, intracellular enzyme functions, protein stability, and other molecular interactions. By having a bodily pH outside of the optimal range, we begin to see a reduction in these molecular movements of white blood cells toward the invading pathogens. Therefore, the overall immune response is weakened when an excessive extracellular pH imbalance is present.

Age, Stress, Bone Loss & Body pH

 

Age, stress, sedantary lifestyle, and unhealthy diet all contibutes early onset of osteopedia and osteoporosis.  When we start to lose the bone mass, calcium and phosphorus start to flood our system.  After calcium is used up by our cells, phosphorus reacts with water and stays in our blood as 80% hydrogen phosphate (HPO4–) and 20% dyhydrogenphosphate (H2PO4-) which acts as strong acid making our body more acidic.  This process donates more protons (H+) which further contributes to the lowering of the pH.

In acidic environment, our hemoglobin delivers mush less oxygen to the cells of our body, further contributing to lower pH and the lower pH makes our immune system far less effective, especially cytotoxic T-lymphocyte and NK cell functions. When pathogens like virus and bacteria invade our cells, the process makes extracellular pH even more acidic by producing and excrete more H+ during the process of virus replication, suppressing our immune system to be even less effective.

Combined with stress and poor diet that also contributes to the lower pH of our body, people of modern days are powerless against infections from virulent pathogens such as SARS and MERS.  Antibiotics that may destroy the immune helping gut microbiome is not the lasting solution, either.

SAC Therpy neutralizes acids to bring our body’s pH to ideal slight alkaline level where immune response is optimized to mount attack on pathogens.

RESEARCH: Pathogen Proliferation and body pH

Virus Infection Lowers Extracellular pHe

 

“Several studies have reported that large amounts of RNA are synthesized within a short period after the influenza virus enters the cell, thereby suggesting that the rate of ATP consumption would be higher in influenza virus-infected cells than in uninfected cells (Guinea and Carrasco, Hui and Nayak). The virus-infected cells synthesize some ATP by oxidative metabolism, and some by glycolysis. Glycolysis is the metabolic pathway that converts glucose (C6H12O6) into pyruvate (CH3COCOO + H+). Pyruvate can be converted into lactate reversibly. High rates of glycolysis and lactate are reported as a common feature of virus-infected cells (Allison; Singh et al). This follows from the intimate association between lactate and H+ gradient across the cell plasma membrane (Allison). One obvious hypothesis is that the export of metabolic acids (lactate and CO2) and H+ from the cell into the near-surroundings will acidify the extracellular compartment. Some researchers have reported a reduction in intracellular pH (pHi) of virus-infected cells (Steinhauer et al.; Ciampor et al).”

Front Microbiol. 2016; 7: 1127

“The decrease in pHe near the cell membrane after virus infection should be related with two factors: the H+ produced in the cytoplasm and its release into the extracellular environment. First, high rates of glycolysis are required to produce more ATP which is necessary for large amounts of virus replications in host cell. The glycolysis will produce more metabolic acids and H+ in cytoplasm. Actually, many researches have reported that there was 0.3–0.4 unit reduction in pHi of virus-infected cells (Steinhauer et al, Ciampor et al.). The decrease in pHi of virus-infected cell is not only related with glycolysis but also the functions of M2 protein embedded in the viral lipid membrane.”

RESEARCH: Interplay between Extracellular Acidosis and Immune Cells

“Both the innate and adaptive arms of the immune response appear to be finely regulated by extracellular acidosis in the range of pH values found at inflammatory sites and tumors. Low pH has been shown to delay neutrophil apoptosis, promoting their differentiation into a proangiogenic profile. Acting on monocytes and macrophages, it induces the activation of the inflammasome and the production of IL-1., while the exposure of conventional dendritic cells to low pH promotes the acquisition of a mature phenotype. Overall, these observations suggest that high concentrations of protons could be recognized by innate immune cells as a danger-associated molecular pattern (DAMP).”

“On the other hand, by acting on T lymphocytes, low pH has been shown to suppress the cytotoxic response mediated by CD8+ T cells as well as the production of IFN-γ by TH1 cells. Interestingly, modulation of tumor microenvironment acidity has been shown to be able not only to reverse anergy in human and mouse tumor-infiltrating T lymphocytes but also to improve the antitumor immune response induced by checkpoint inhibitors. Here, we provide an integrated view of the influence exerted by low pH on immune cells and discuss its implications in the immune response against infectious agents and tumor cells.”

Mediators of Inflammation, Volume 2018, Article ID 1218297, 11 pages

SAC Therapy Removes 'Building Materials' Used by Pathogens to Multiply

The way the virus replicates depends on the presence of phosphates in the form of copolymerization with ribose and nucleus. From the time we start to lose our bone mass (around age 40+), phosphorus is taken out together with calcium from our bones, providing more ‘building materials’ which pathogens can utilize to proliferate rapidly.

With SAC therapy which triggers bone bulding processes, the access phophorus along with excess calcium is sent back to bones to be deposited.  This process eliminates ‘building materials’ for pathogens and gives our body’s adaptive immune system more time to get ready and launch a massive retaliatory measure against pathogens, before viral overload and associated symptoms (including inflammatory responses by our immune system) overwhelm our immune system to our own demise.  This is a very important countermeasure often overlooked in antiviral or antibacterial strategy.

“A high school student with aplastic anemia was going through a rough patch because the only available treatment option for his condition was bone marrow transplant. However, after being introduced to SAC therapy, he fully recovered from aplastic anemia. After graduating from college, he got a job at a hospital as a phlebotomist around 2015 when there was a MERS epidemic in South Korea.

His team, who received and diagnosed MERS patients, were all quarantined due to MERS infection, except this young man. It was a mystery to all his colleagues why only he escaped MERs contraction when he was at the riskiest position of drawing the blood of MERS patients as a phlebotomist. The only difference was that he was still taking SAC at a maintenance dosage.”

A Patient Testimony from Dr. Paul K. Lee

Sample Clinical Results from HIV Patients under SAC Therapy

Patients have taken MaraGen 2-3 times a day and the viral load dropped significantly in relatively very short period of time.  CD4 count was not reported by the patients/physicians.  The study was not conducted long enough to find if SAC therapy helps our immune system to completely eradicate the virus.

SAC Therapy & Lyme Disease

Truly Debilitating Effects of Lyme Disease

 

Lyme borreliosis is transmitted through the bite of a tick that is infected by the bacterial spirochete Borrelia burgdorferi. Clinical manifestation of the disease can lead to heart conditions, neurological disorders, and inflammatory disorders, and once infected, B. burgdorferi disseminates and causes a variety of immunological and inflammatory reactions throughout the body.

Early manifestations of infection can lead to heart complications (e.g. carditis, dizziness, palpitations), neurological disorders (e.g. Bell’s and/or cranial nerve palsy, peripheral neuropathy), and other inflammatory disorders (e.g. head and neck aches (meningitis), arthritis).

If treatment is ineffective (Post-Treatment Lyme Disease Syndrome) or if infected individuals remain undiagnosed and untreated, some symptoms can persist for months to years. These symptoms may include muscular pains, arthritis, neurological disorders, fatigue, etc.

Lyme tick and B. burgdorferi bacteria

RESEARCH:  Abstract

 

The aim of this study was to investigate the mechanisms of oxidative stress and intracellular communication in Lyme borreliosis patients. Mitochondrial superoxide and cytosolic ionized calcium was measured in peripheral blood mononuclear cells (PBMCs) of Lyme borreliosis patients and healthy controls. Mitochondrial superoxide levels were significantly higher in Lyme borreliosis patients as compared to healthy controls. Significantly low levels of cytosolic ionized calcium were also observed in Lyme borreliosis patients when compared to healthy controls. These results indicate that there is an imbalance of reactive oxygen species and cytosolic calcium in Lyme borreliosis patients. The results further suggest that oxidative stress and interrupted intracellular communication may ultimately contribute to a condition of mitochondrial dysfunction in the immune cells of Lyme borreliosis patients.

Elsevier B.V. This is an open access article under the CC BY license 

Lyme Disease Causes Oxidate Stress

 

“… that by reducing mitochondrial ROS a resulting down regulation of NADPH oxidase occurred which ultimately broke the cycle causing oxidative stress in the cell….

In conclusion, our results have shown a significant rise in mitochondrial superoxide, indicative of a state of oxidative stress in the PBMCs of Lyme borreliosis patients.”

The rise of mitochondrial superoxide is closely related to excess ionic calcium storage in the cell membranes mitochondria.  SAC therapy, by restoring calcium homeostasis, regulates the buffering capacity of cellular ionic reservoirs like mitochondria and ER, restores the functions of mitochondria that is responsible for oxidate stress caused by the rise of superoxide production. 

Lyme Disease Depletes Ca2+

 

Since Lyme borreliosis is an infection that can lead to a severe inflammatory state, we assessed the levels of cytosolic Ca2+ in infected patient PBMCs compared with uninfected individuals (Table 1B). Our observations (Fig. 2) have shown a significant decrease in the levels of cytosolic Ca2+ in PBMCs of Lyme borreliosis patients when compared to healthy controls.

By restoring calcium homeostasis, SAC therapy can regulate the proper intracellular concentration of ionic calcium which is essential for correct cellular responses.  Disruption of proper ionic calcium concentration wrechks havoc in all our systems.

Lyme Disease Causes Mitochondrial Dysfunction

 

“These results indicate that there is an imbalance of reactive oxygen species (ROS) and cytosolic calcium in Lyme borreliosis patients. The results further suggest that oxidative stress and interrupted intracellular communication may ultimately contribute to a condition of mitochondrial dysfunction in the immune cells of Lyme borreliosis patients.”

By restoring calcium homeostasis, SAC restores proper level of intracellular calcium ion level to restore cellular communication and mitochondrial function, reducing ROS production and free radicals which causes inflammation. SAC essentially reverses the mitochondrial damage caused by Lyme Disease.

By maintaining the ideal body pH to 7.4, SAC inhibits the proliferation of B. Burgdorferi and reduces inflammation through alkalizing effect. Also, by taking excess phosphorus back to the bone, B. Burgdorferi multiplication is hampered.

Lyme Disease
Testimony

Mike Kim. 11 year-old boy, infected with Lyme disease.
Experienced fatigue, fever, migraine, muscle aches, etc.
Antibiotics, pain killers did not improve symptoms.
Has taken Margen 3x a day. All the symptoms disappeared in about 40 days. Bacterial count is negligible. Currently, living
a normal life, taking 1x daily of maintenance dosage.

A Patient Testimony from Dr. Paul K. Lee

SAC Repairs Cellular to Systemic Functions to Help our Body to Fight Infections Better

SAC is the world’s first calcium-ion-delivery-system, which safely and effectively elevates the level of calcium-ion concentration in our blood. By utilizing a very weak chemical bonding, namely sigma antibonding, to calcium carbonate molecules, Calcium & Bone Health Institute of Canada (CBHI) invented new calcium carbonate, which maintains loosely held calcium ion to its carbonate group.

Because of the weak chemical bonding of SAC, calcium ion is easily detached and passively absorbed into our system through stomach lining as ions via diffusion and osmotic pressure, not requiring digestion, vitamin D, nor peptides for absorption.  This is called passive transport. Because of our body’s natural sensitivity to fluctuations of serum plasma ionic calcium level, a minimal elevation of ionic calcium concentration achieved by SAC can trigger hormonal responses, such as the release of TSH and calcitonin to trigger bone-building osteoblasts.

SAC therapy utilizes ionic calcium as a signaling agent to trigger our body’s natural responses to increase bone turnover rate in repairing and rebuilding bones and in the due process also eliminates body-wide calcification even from overloaded cellular reservoirs.  Restored calcium homeostasis leads to restoring mitochondria functions, correcting calcium signaling, and mitigating oxidative stress.  Healthy cells to systems maintain optimal immune response and environment that protect us from the invations of pathogens.  SAC’s healing pathway from infectious disease is genuinely unique without side effects experienced in prescription drugs.

The 4 Functions of SAC Calcium for Infectious Diseases

SAC Maintains Slightly Alkaline pH

Accumulation of protons in the extracellular space is frequently associated with the course of inflammatory responses against bacteria in peripheral tissues, where pH values as low as 5.5 have been described. Low pH turns off many immune responses.

SAC provides ionic calcium for neutralizing extracellular spaces to turn on strong immune responses against pathogen.

SAC Inactivates Viral RNA Replication

The way the virus replicates depends on the presence of phosphates in the form of copolymerization with ribose and nucleus.

SAC increases fluid ionized calcium levels in plasma, intracellular and extracellular spaces, which forms a complex with phosphates and deactivates viral RNA.

SAC Strengthens Immune Responses

Killing pathogens by cytotoxic T-lymphocytes (CTL) and by natural killer (NK) cells is of vital importance.

Raising intracellular ionic calcium concentrations optimizes killing efficiency of is cytotoxic T-lymphocytes (CTL) and NK cell as several steps of the actual killing process are calcium dependent.

SAC Removes Virus Building Materials

The way the virus replicates depends on the presence of phosphates in the form of copolymerization with ribose and nucleus.

SAC,  by triggering bone bulding process, takes access phophorus back to bones, eliminating ‘building materials’ for pathogens to multiply. This gives our body’s adaptive immune system more time to get ready and launch a massive retaliatory measure against pathogens.

Decalcification Effects of SAC Therapy

Removing Calcification from Cellular to Systemic Level is a Key to Recovery

Physiological Effects of SAC

After intake, SAC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.

While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking SAC is experienced, which is both healthy and normal, indicating that SAC is working.

STRONGER BONES LEAD TO A HEALTHIER LIFE

A long term, follow up study done in Denmark for 35,000 people revealed that the people with strong bones in their 50’s lived 11.6 years longer.
YET, in Canada, 49% of infants are born with calcium deficiency. Only 70% recover after breastfeeding. Calcium deficiency during pregnancy and infancy leads to serious health issues.

Bone Loss Leads to 150+ Degenerative Diseases

Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates not only a higher risk of fracture but also a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.

Conditions Commonly Treated with SAC Therapy

Cellular Recovery Helps to Restore Mitochondrial Function & Reduce Oxidative Stress

  • Autoimmune disease (Lupus, Vitiligo, Hashimoto’s, Crohn’s, Celiac disease, eczema, MS, rheumatoid, etc.)
  • Lyme disease, HIV, Shingles and other viral infections
  • Parkinson’s, ALS, Alzheimer’s and
    other neurodegenerative diseases
  • Arthritis, Gout, CPPD, Inflammations
  • Mitochondrial Disease
  • Cancer (carcinoma, sarcoma,
    lymphoma, leukemia, multiple
    myeloma)
  • Arrhythmia, Heart palpitation, Mitral Valve Prolapse,
  • Diabetes, Metabolic Syndrome
  • Thrombosis, Hemolytic Anemia
  • Autism Spectrum Disorder,
  • ADHD, Epilepsy
  • Asthma, COPD
  • Glaucoma, Cataract, Intermittent Exotropia, Retinal Vein Occlusion
  • Menier’s Disease, Aurora Migraine
    Disease, Tinnitus, Vertigo
  • Osteoporosis, Bone Necrosis
  • Chromosome 8 syndrome
  • Chronic Kidney Disease
  • Gum disease, Loose teeth
  • Calcification (joints and tissues),
    Calcific tendonitis, Fibrosis, Kidney
    and Gall Bladder Stones
  • Dysmenorrhea, infertility