was successfully added to your cart.

SAC & Heart Health

By April 9, 2020Resources, SAC

SAC Therapy and Heart Health

Restoring Cellular Signaling of Every Heart Cells for Properly Orchestrated Organ Functions

SAC in a

SAC (Sigma Antibonding Calcium Carbonate) is the only true ionic calcium delivery system that provides calcium in a free ionic state, which is the only physiologically active form of calcium in our body. Normally, calcium from diet and supplements enters our body in the protein-bound form and, therefore, cannot trigger the same physiological responses as SAC. Resolving calcium deficiency better than protein-bound calcium, SAC triggers ionic-calcium-sensitive physiological responses that counteract the root cause of diseases and brings natural healing reactions of our body from cellular to the systemic level.

Cardiovascular Disease is the #1 Killer Globally

CVD Facts from WHO

  • CVDs are the number 1 cause of death globally: more people die annually from CVDs than from any other cause.
  • An estimated 17.9 million people died from CVDs in 2016, representing 31% of all global deaths. Of these deaths, 85% are due to heart attack and stroke.
  • Over three quarters of CVD deaths take place in low- and middle-income countries.
  • Out of the 17 million premature deaths (under the age of 70) due to noncommunicable diseases in 2015, 82% are in low- and middle-income countries, and 37% are caused by CVDs.
  • Most cardiovascular diseases can be prevented by addressing behavioural risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol using population-wide strategies.
  • People with cardiovascular disease or who are at high cardiovascular risk (due to the presence of one or more risk factors such as hypertension, diabetes, hyperlipidaemia or already established disease) need early detection and management using counselling and medicines, as appropriate.

Types of Heart Disease


Atherosclerosis is a condition that develops when a substance called plaque builds up in the walls of the arteries. This buildup narrows the arteries, making it harder for blood to flow through. If a blood clot forms, it can block the blood flow. This can cause a heart attack or stroke.

Heart attack

A heart attack occurs when the blood flow to a part of the heart is blocked by a blood clot. If this clot cuts off the blood flow completely, the part of the heart muscle supplied by that artery begins to die.

Heart failure

Heart failure, sometimes called congestive heart failure, means the heart isn’t pumping blood as well as it should. Heart failure does not mean that the heart stops beating — that’s a common misperception. Instead, the heart keeps working, but the body’s need for blood and oxygen isn’t being met.


Arrhythmia refers to an abnormal heart rhythm. There are various types of arrhythmias. The heart can beat too slow, too fast or irregularly. Bradycardia, or a heart rate that’s too slow, is when the heart rate is less than 60 beats per minute. Tachycardia, or a heart rate that’s too fast, refers to a heart rate of more than 100 beats per minute.

Heart valve problems

When heart valves don’t open enough to allow the blood to flow through as it should, a condition called stenosis results. When the heart valves don’t close properly and thus allow blood to leak through, it’s called regurgitation. If the valve leaflets bulge or prolapse back into the upper chamber, it’s a condition called prolapse.

Types of Drugs for Heart Disease

Angiotensin II receptor blockers (ARBs): These are used to lower blood pressure for people with heart failure. They help keep your blood vessels as wide as possible so blood can flow through your body more easily. They also lessen salt and fluid buildup in your body.

Aldosterone inhibitors: These are called potassium-sparing diuretics.  They can ease the swelling and water buildup heart disease can cause. They help the kidneys send unneeded water and salt from your tissues and blood into your urine to be released.

ACE inhibitors: These widen arteries to lower your blood pressure and make it easier for your heart to pump blood.

Beta-blockers: They block the effects of adrenaline  (epinephrine). This helps your heart work better. These meds also drop production of harmful substances your body makes in response to heart failure. And they cause your heart to beat slower and with less force. Those both lower your blood pressure.

Calcium channel blockers: These treat chest pain (angina) and high blood pressure.  They relax blood vessels and increase blood and oxygen to your heart. That eases its workload.

They treat heart failure caused by bypertension.  But they’re used only when other medicines to lower blood pressure don’t work.

Cholesterol-lowering drugs: Inflammation may force cholesterol to build up in the walls of your arteries. That buildup increases your chance of having a heart attack or stroke.

Digoxin: It helps an injured or weakened heart to send blood through the body and work more efficiently. It strengthens the force of the heart muscle’s contractions.

Diuretics: You may know these as water pills. They help your kidneys get rid of unneeded water and salt from your tissues and bloodstream. That makes it easier for your heart to pump. They treat high blood pressure and ease swelling and water buildup caused by some medical problems, including heart failure

Inotropic therapy: This helps make an injured or weakened heart pump harder to send blood through the body. It helps strengthen the heart muscle’s contractions. It also relaxes constricted blood vessels so blood can flow more smoothly. Inotropic therapy may also speed up your heart’s rhythm.

Vasodilators: These relax your blood vessels so blood can flow more easily through your body. You’ll get these if you can’t take ACE inhibitors.

Warfarin: This helps prevent clots from forming in your blood. You’ll get it if your body is making blood clots, or if you have a condition that helps cause them.

Side Effect of Heart Drugs

Each type of coronary heart disease medication has different side effects.

Antiplatelet drugs can cause diarrhea, rash, or itching, abdominal pain, headache, chest pain, muscle aches, and dizziness.

Side effects of anticoagulants are bleeding and necrosis (gangrene) of the skin.

Side effects of angiotensin converting enzyme (ACE) inhibitors include cough, elevated blood potassium levels (hyperkalemia), low blood pressure, dizziness, headache, drowsiness, weakness, abnormal taste, and rash.

Taking vasodilators may cause lightheadedness or dizziness, increased or irregular heart rate, or headache.

Side effects of calcium channel blockers include constipation, nausea, headache, rash, edema, low blood pressure, drowsiness, and dizziness.

Anti-arrhythmics may cause dizziness, blurred vision, anorexia, unusual taste, fatigue, nausea and vomiting.

Ionic Calcium Supports Healthy Mitochondrial Functions in Heart Cells

In this experiment performed by CBHI, Canada, a rat’s heart tissue was left outside in vitro to grow cold. After SAC is added to provide ionic calcium, the tissue cells’ mitochondria generated energy, and the temperature increase is indicated in the infrared pictures below. In another experiment, an extracted rat’s heart continued to pump as ionic calcium solution flowed through it.

The Role of Ionic Calcium in Heart Contraction & Relaxation Cycle

A heart uses Ca2+ to achieve a synchronized cellular depolarization and subsequent activation of contractile proteins, via the physiological mechanism of excitation-contraction coupling (EC coupling).

To facilitate this process, intracellular Ca2+ homeostasis must be carefully regulated to ensure that depolarization and contraction occur in a synchronized time-dependent fashion during the systolic-diastolic cycle of the heart. With aging, ionic homeostasis is deregulated for most people. SAC Therapy helps to restore this crucial process in reset EC coupling to its correct state. 

SAC Therapy Switches Our Body Back to Non-Calcification Mode

From the time we start to lose our bone mass (around age 40+), our body slowly enters calcification mode where body-wide calcification happens at an accerated rate.  (When we multiply the serum concentration of calcium with phosphorus and the product is greater than 55-60 mg/dL, we are in the calcification mode.)  Below is a diagram of a sample calculation.  With SAC therapy where both calcium and phosphorus find its way back to bones, one no longer remains in calcification mode, helping our heart to recover.

Calcium Homeostasis is a Key to Healthy Heart

Cardiac Exitation-Contraction (EC) coupling refers to the coordinated cellular depolarization and movement of intracellular Ca2+ around the cell in order to bring about contraction. It is the key Ca2+ signaling process within the heart and its cellular components. Cellular calcification, which happens to everyone as we age, reduces the cell’s ability to store and regulate calcium concentrations within cytosol.

The inward Ca2+ current (ICa) through DHPR is, on its own, insufficient to bring about the required conformational change in troponin needed for contraction to occur. Additional Ca2+ is required and this is obtained from a pool of stored Ca2+ within the sarcoplasmic reticulum (SR) of the cell. The initial inward movement of Ca2+ acts as an amplification signal for the release of this stored pool of SR.  However, cellular calcification, make this process inefficient.

SAC Therapy, which triggers de-calcification effect of cells help restore the ‘definition’ of calcium signaling to helps heart cells contract properly and fully.

Pathological Cellular Ionic Calcium Overload Causes Heart Failure

“It is not surprising that a physiological mechanism such as EC coupling, which utilizes Ca2+ as a second messenger, should be implicated in both arrhythmia and heart failure pathogenesis…. Although it has been long appreciated that pathological cellular Ca2+ overload can lead to a pro-arrhythmogenic state it is only recently that a clearer understanding of the importance of defective Ca2+ signaling in arrhythmia pathogenesis” has emerged.”

Biochemical & Biophysical Research Communications, 322 (2004) 1286-1309

Calcium Homeostasis & Organ Scale Heart Rhythm Disruptions

“Cardiac arrhythmia, caused by disruption of the coordinated electrical activity of heart, is among the leading causes of sudden cardiac death in United States…. Intracellular calcium dynamics in cardiac cells have been recognized as an important contributor in life-threatening ventricular arrhythmia (ventricular tachycardia and ventricular fibrillation) as well as increasingly prevalent atrial arrhythmias (atrial fibrillation [AF] and flutter).”

Clinical Medicine Insights: Cardiology, Volume 11: 1-4

“I developed a Mitral valve prolapse heart condition that in which the two valve flaps of the mitral valve do not close smoothly or evenly, but instead bulge upward into the left atrium. I was a sprinter in my high school years but then I could not climb the stairs or run. My heart pain continued and the Richmond Cardiologist, Dr. Broumand, told me that my life stopwatch started and I was dying....

I was then introduced to Pronuvia’s scientific discoveries and innovation during the winter of 2010. On or about Spring of 2011, I tried some of the SAC Calcium products and I immediately felt the increase in my energy. Three months after taking SAC Calcium I began walking on my treadmill. Initially, I walked for 15 minutes but after 2 months I began jogging.”

E. Baragoosh, 59, Male, Canada

SAC Repairs Cellular Functions to Organ Scale Functions

SAC is the world’s first calcium-ion-delivery-system, which safely and effectively elevates the level of calcium-ion concentration in our blood. By utilizing a very weak chemical bonding, namely sigma antibonding, to calcium carbonate molecules, Calcium & Bone Health Institute of Canada (CBHI) invented new calcium carbonate, which maintains loosely held calcium ion to its carbonate group.

Because of the weak chemical bonding of SAC, calcium ion is easily detached and passively absorbed into our system through stomach lining as ions via diffusion and osmotic pressure, not requiring digestion, vitamin D, nor peptides for absorption.  This is called passive transport. Because of our body’s natural sensitivity to fluctuations of serum plasma ionic calcium level, a minimal elevation of ionic calcium concentration achieved by SAC can trigger hormonal responses, such as the release of TSH and calcitonin to trigger bone-building osteoblasts.

SAC therapy utilizes ionic calcium as a signaling agent to trigger our body’s natural responses to increase bone turnover rate in repairing and rebuilding bones and in the due process also eliminates body-wide calcification even from overloaded cellular reservoirs.  Restored calcium homeostasis leads to restoring mitochondria functions, correcting calcium signaling, and mitigating oxidative stress.  Combined with organ-scale decalcification achieved by SAC, heart muscles contract properly and correctly as EC couple signalling is corrected from the cellular level.  SAC’s healing pathway is genuinely unique without side effects experienced in prescription drugs.

The 4 Functions of SAC Calcium for Hearts

SAC Corrects Proper Signalling

EC coupling of our heart, which is responsible for precise signalling of heart muscles to contract properly at the right timing, is a concerted work of complex calcium signalling in the cellular level. As we age, cellular calcification disrupts calcium signalling which affects EC coupling of our heart.

SAC restores calcium homeostasis which helps to restore calcium signalling for heart cells function properly, repairing EC coupling deterioration.

SAC Clears Calcium Deposits

With aging, our thinning bones cause body-wide calcification, depositing stiffening calcium in the soft tissues, around joints, and even in cellular spaces.  also, stressed blood vessels around the heart tend to collect plaque which is cemented with calcium.

SAC triggers body-wide decalcification as it sends calcium and phosphorus back to the bones, significantly reducing the calcification factor, reducing and even reversing calcification, protecting and restoring our precious heart and vessels to bear the load better.

SAC Repairs Damaged Tissues

Our heart is one of the hardest working organ in our body.  Daily, the heart pumps at least 2,500 gallons and beats over 3 billion times in a person’s life.  With aging comes wear and tear of the organ.

By providing the optimum environment for our body’s own mesenchymal stem cells to proliferate and repair damaged cells, SAC helps our heartmuscle to receive the daily repair it needs.

SAC Strengthens Structural Intergrity

The cardiac skeleton consists of dense connective tissue, as collagen, that encircle the bases of the pulmonary trunk, aorta, and heart valves and providse structure and support for the heart, as well as isolate the atria from the ventricles. However, we age collagen matrix of this connective tissue is weakened, affecting the functions of heart.

Ionic calcium is one of the best signaling agents that stimulates the stem cells for the repairing and rebuilding of the collagen matrix and connective tissue, supporting structural integrity for our hearts.

Decalcification Effects of SAC Therapy

Removing Calcification from Cellular to Systemic Level is a Key to Recovery

Physiological Effects of SAC

After intake, SAC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.

While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking SAC is experienced, which is both healthy and normal, indicating that SAC is working.


A long term, follow up study done in Denmark for 35,000 people revealed that the people with strong bones in their 50’s lived 11.6 years longer.
YET, in Canada, 49% of infants are born with calcium deficiency. Only 70% recover after breastfeeding. Calcium deficiency during pregnancy and infancy leads to serious health issues.

Bone Loss Leads to 150+ Degenerative Diseases

Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates not only a higher risk of fracture but also a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.

Conditions Commonly Treated with SAC Therapy

Cellular Recovery Helps to Restore Mitochondrial Function & Reduce Oxidative Stress

  • Autoimmune disease (Lupus, Vitiligo, Hashimoto’s, Crohn’s, Celiac disease, eczema, MS, rheumatoid, etc.)
  • Lyme disease, HIV, Shingles and other viral infections
  • Parkinson’s, ALS, Alzheimer’s and
    other neurodegenerative diseases
  • Arthritis, Gout, CPPD, Inflammations
  • Mitochondrial Disease
  • Cancer (carcinoma, sarcoma,
    lymphoma, leukemia, multiple
  • Arrhythmia, Heart palpitation, Mitral Valve Prolapse,
  • Diabetes, Metabolic Syndrome
  • Thrombosis, Hemolytic Anemia
  • Autism Spectrum Disorder,
  • ADHD, Epilepsy
  • Asthma, COPD
  • Glaucoma, Cataract, Intermittent Exotropia, Retinal Vein Occlusion
  • Menier’s Disease, Aurora Migraine
    Disease, Tinnitus, Vertigo
  • Osteoporosis, Bone Necrosis
  • Chromosome 8 syndrome
  • Chronic Kidney Disease
  • Gum disease, Loose teeth
  • Calcification (joints and tissues),
    Calcific tendonitis, Fibrosis, Kidney
    and Gall Bladder Stones
  • Dysmenorrhea, infertility