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SAC & Brain Health

By April 10, 2020Resources, SAC

SAC Therapy and Brain Health

Pathogenesis of Neurodegenerative Diseases is Linked to Disrupted Calcium Homeostasis in Brain Cells. SAC Helps to Restore It.

SAC in a

SAC (Sigma Antibonding Calcium Carbonate) is the only true ionic calcium delivery system that provides calcium in free ionic state, which is the only physiologically active form of calcium in our body. Normally, calcium from diet and supplements enters our body in the protein-bound form and therefore, cannot trigger the same physiological responses as SAC. Resolving calcium deficiency better than protein-bound calcium, SAC triggers ionic-calcium-sensitive physiological responses that counteract the root cause of diseases and brings natural healing reactions of our body from cellular to the systemic level.

Is Neurodegenerative Diseases Inevitable with Age?

Neurodegenerative disease is an umbrella term for a range of conditions which primarily affect the neurons in the human brain.

Neurons are the building blocks of the nervous system which includes the brain and spinal cord. Neurons normally don’t reproduce or replace themselves, so when they become damaged or die they cannot be replaced by the body. Examples of neurodegenerative diseases include Parkinson’s, Alzheimer’s, ALS, and Huntington’s disease.

Neurodegenerative diseases are considered incurable and debilitating conditions that result in progressive degeneration and / or death of nerve cells. This causes problems with movement (called ataxias), or mental functioning (called dementias).  Today, 5 million Americans suffer from Alzheimer’s disease; 1 million from Parkinson’s; 400,000 from multiple sclerosis (MS); 30,000 from amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease), and 30,000 from Huntington’s disease.


Examples of Neurodegenerative Diseases :

  • Alzheimer’s disease (AD) and other dementias
  • Parkinson’s disease (PD) and PD-related disorders
  • Aamyotrophic lateral sclerosis (ALS)
  • Prion disease
  • Motor neurone diseases (MND)
  • Huntington’s disease (HD)
  • Spinocerebellar ataxia (SCA)
  • Spinal muscular atrophy (SMA)

Is Prescription Drugs Effective for Neurodegenerative Diseases?

Currently, no neurodegenerative disease is curable, and the treatments available only manage the symptoms or halt the progression of the disease. Therefore, there is an urgent need for new treatments for this kind of disease, since the World Health Organization has predicted that neurodegenerative diseases affecting motor function will become the second-most prevalent cause of death in the next 20 years.

Since there are no effective treatments for degenerative diseases in modern society, many doctors use Western medicine to deal with the acute disorders or symptoms and use the advantages of other integrative treatments to assist Western medicine in improving the patients. Integrative medicine can, sometimes, exhibit protective effects or slow the morbidity of these diseases.

Mitochondrial Free Radical Theory

A large accumulation of calcium ion inside of mitochondrial membranes induces the over production of Reactive Oxygen Species (ROS), which causes damage to DNA, RNA, and proteins, which results in cell mutation, being the main driving force of aging, neurodegenerative diseases, and even cancer. There is no plant based antioxidents we can take to neutralize all the free radicals produced by our own mitochondria. Mitochondrial damage also forces cells to undergo fermentation, which upregulates genes to support fermentation, a leading step towards cancer.

Restoring cellular calcium homeostasis, which is achieved through SAC Therapy, reduces the cause of ROS production by eliminating excess calcium ions from mitochondria and rejuvenating our cellular powerhouse.  SAC Therapy gets to the very bottom and resolves the very root cause of degenerative diseases.

Research: Perturbed Calcium Homeostasis Causes Alzheimer's Disease

“Collectively, the available data show that perturbed cellular calcium homeostasis plays a prominent role in the pathogenesis of AD, suggesting potential benefits of preventive and therapeutic strategies that stabilize cellular calcium homeostasis.”

Research: Ca2+ Signaling Abnormalities in Alzheimer's Disease

“Because of these Ca2+ signaling abnormalities, a balance in activities of Ca2+-calmodulin dependent kinase II (CaMKII) and Ca2+-dependent phosphatase calcineurin (CaN) is shifted at the synapse… As a result, synapses are weakened and eliminated in AD brains by LTD mechanism, causing memory loss. Targeting synaptic calcium signaling pathways offers opportunity for development of AD therapeutic agents.”

Ca2+ Overload in the Pathogenesis of Alzheimer’s

Amyloid-targeting therapies to treating Alzheimer’s Disease (AD) has failed in clinical trials.  A new research finds that abnormal calcium signaling in AD neurons can cause AD pathogenesis. (Popugaeva & Bezprozvanny, 2013)

AD neurons exhibit enhanced intracellular calcium (Ca2+) liberation from the endoplasmic reticulum (ER) and reduced store-operated Ca2+ entry (SOC) which leads to ER Ca2+ overload

Ca2+ Overload leads to Mitochondrial Defects

When Ca2+ increases, the reactive oxygen species (ROS) production is also increased.

Mitochondria plays a key role in intracellular Ca2+ handling.

Loss of mitochondrial membrane potential followed by release of ROS causing oxidative stress, and apoptogenic drivers in astrocytes.

Aβ-activated astrocytes were co-cultured with neurons; and the neurons died within 24 hours unless the Aβ-induced Ca2+ oscillation was prevented which causes synaptic failure; the onset of AD pathogenesis.

Effects of Calcium Homeostasis in Neurons

Neurons are highly susceptible to changes in intracellular Ca2+ concentration.  Insufficient intracellular Ca2+ content lead to abnormal functioning of neurons while excessive Ca2+ levels cause cell death.

There are observation that link Aβ42 accumulation with elevated Ca2+ levels in neuronal cytoplasm in Vivo.

It has been shown that oligomers of Aβ are able to make Ca2+ permeable channels in plasma membrane of neurons, which directly affect on intracellular Ca2+ concentration.

Research: The Role of Calcium Signaling in Parkinson's Disease

This Review discusses current evidence that implicates Ca2+ in the pathogenesis of Parkinson’s disease. Understanding the mechanisms by which Ca2+ signaling contributes to the progression of this disease will be crucial for the development of effective therapies to combat this devastating neurological condition.  An emerging, key pathological feature caused by α-synuclein aggregation is the disruption of calcium (Ca2+) homeostasis.

Because Ca2+ signaling affects all aspects of neuronal cell biology, cells must tightly regulate Ca2+ levels to avoid uncontrolled responses that could otherwise lead to pathological conditions and cell death.

Research: Calcium, Mitochondria, and the Pathogenesis of ALS

“It has become obvious that the lack of understanding of the precise mechanisms of motor neuron degeneration presents a major obstacle in the development of effective therapies for ALS.

Altered calcium homeostasis and calcium signaling pathway activation is one potential mechanism that accounts for at least three major and interrelated toxic pathways: oxidative stress, mitochondrial dysfunction and neuroinflammation in neurodegenerative diseases such as ALS.”

“These findings are in good agreement with a quantitative comparison of Ca2+ homeostasis where low cytosolic Ca2+ buffering capacity acts as an important risk factor for degeneration, and in contrast an increase in cytosolic Ca2+ buffering capacity could protect vulnerable MNs from degeneration both in-vitro and in-vivo.”

SAC Therapy, as it triggers body-wide decalcification in building bones, clears cellular calcification and restores the ionic calcium buffering capacity of ER and mitochondria.  Therefore, SAC therapy’s effects on neurodegenerative diseases are in alignment with many researches that suspects disruptions of calcium homeostasis in brain cells as the major cause.

Research: Calcium Signaling Orchestrates Glioblastoma Development

“Accumulating evidence suggests that Ca2+ might also be an important positive regulator of tumorigenesis in Gioblastoma Multiform(GBM), in processes involving quiescence, maintenance, proliferation, or migration…”

Research: Calcium Homeostasis in Multiple Sclerosis

“There are indications for disturbances in calcium homeostasis in MS patients, contribution to MS pathogenesis…. Balanced calcium homeostasis is essential for the efficient function of cells and organism.”

Examples of Cellular Calcium Signalling

“A 65-year-old male with late-stage ALS was not able to go to the toilet by himself but was able to go to the toilet alone after taking SAC calcium for 3~4 days.”

“A 53-year-old male often had swallowing difficulties due to neck muscle weakness. He was able to swallow food easily after taking SAC calcium.”

“A 65-year-old female was diagnosed with MS (multiple sclerosis). After taking SAC calcium for 1 week, she was prescribed lower dose aspirin (from 320mg to 80mg), and her circulation functions were also improved.”

Patients Testimony by Dr. Paul Lee

“An 85-year-old male (USA) was diagnosed with Alzheimer’s. He would often veer to one side and often fall by losing balance. Early symptoms of Alzheimer’s disappeared and balance was restored after taking SAC calcium for two months.”

“An elderly female dementia patient (Manila) who could not remember her family members for the past three years regained her memory and recognized family after taking SAC calcium for 5 months.”

“A 19-year-old male (USA) was diagnosed with early-stage ALS. Early symptoms of ALS disappeared after taking SAC calcium for two months.”

Patients Testimony by Dr. Paul Lee

“Dear Dr. Paul Lee,

Here is an update of the patient with Parkinson’s disease. I saw him in the church today, and he was ecstatic to see me and wanted to share with me his testimonials. He started out taking three bottles of Maragen since October of 2017 without many expectations. However, after others commented that he seems to be doing much better, he was encouraged to take it faithfully through November, twice a day.

He said his tremors almost disappeared! He is 75 years old, and his Parkinson’s was not hereditary but caused by severe stress from his work. After the onset of the disease, his life quality was miserable but now lives a new life because of Maragen. Though he is not a Christian, he came to my church to share the good news with me!”

from H. Shim

A Patient Testimony by Dr. Paul Lee, 75, male, Korea

Decalcification Effects of SAC Therapy

Removing Calcification from Cellular to Systemic Level is a Key to Recovery

Physiological Effects of SAC

After intake, SAC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.

While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking SAC is experienced, which is both healthy and normal, indicating that SAC is working.


A long term, follow up study done in Denmark for 35,000 people revealed that the people with strong bones in their 50’s lived 11.6 years longer.
YET, in Canada, 49% of infants are born with calcium deficiency. Only 70% recover after breastfeeding. Calcium deficiency during pregnancy and infancy leads to serious health issues.

Bone Loss Leads to 150+ Degenerative Diseases

Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates not only a higher risk of fracture but also a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.

Conditions Commonly Treated with SAC Therapy

Cellular Recovery Helps to Restore Mitochondrial Function & Reduce Oxidative Stress

  • Autoimmune disease (Lupus, Vitiligo, Hashimoto’s, Crohn’s, Celiac disease, eczema, MS, rheumatoid, etc.)
  • Lyme disease, HIV, Shingles and other viral infections
  • Parkinson’s, ALS, Alzheimer’s and
    other neurodegenerative diseases
  • Arthritis, Gout, CPPD, Inflammations
  • Mitochondrial Disease
  • Cancer (carcinoma, sarcoma,
    lymphoma, leukemia, multiple
  • Arrhythmia, Heart palpitation, Mitral Valve Prolapse,
  • Diabetes, Metabolic Syndrome
  • Thrombosis, Hemolytic Anemia
  • Autism Spectrum Disorder,
  • ADHD, Epilepsy
  • Asthma, COPD
  • Glaucoma, Cataract, Intermittent Exotropia, Retinal Vein Occlusion
  • Menier’s Disease, Aurora Migraine
    Disease, Tinnitus, Vertigo
  • Osteoporosis, Bone Necrosis
  • Chromosome 8 syndrome
  • Chronic Kidney Disease
  • Gum disease, Loose teeth
  • Calcification (joints and tissues),
    Calcific tendonitis, Fibrosis, Kidney
    and Gall Bladder Stones
  • Dysmenorrhea, infertility