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SAC and Cancer Therapy Copy

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SAC and Cancer Therapy

Attacking Cancer In and Out

Cancer is a genetic disease—that is, it is caused by changes to genes that control the way our cells function, especially how they grow and divide and thus multiply without stopping and spread into surrounding tissues. Cancer can start almost anywhere in the human body.

Normally, human cells grow and divide to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place. When cancer develops, however, this orderly process breaks down, and damaged cells survive when they should die and new cells form when they are not needed. These extra cells can divide without stopping and may form growths called tumors. Cancers of the blood, such as leukemia, generally do not form solid tumors.

Cancerous tumors are malignant and invade nearby tissues. Also, some cancer cells can break off and travel to distant places in the body through the blood or the lymph system and form new tumors far from the original tumor.

How Does Cancer Grow and Spread?

How Cancer Cells Grow Uncontrollably

Cancer cells grow out of control and become invasive because they are able to ignore signals that normally tell cells to stop dividing or begin a process known as programmed cell death, or apoptosis, which the body uses to get rid of unneeded cells.

Also, cancer cells are also often able to evade and hide from the immune system that protects the body from infections and other conditions. Tumors can also use the immune system to stay alive and grow. Moreover, cancer cells may be able to influence the normal cells, molecules, and blood vessels that surround and feed a tumor—an area known as the microenvironment.

How Cancer Arises and Spreads

Each person’s cancer has a unique combination of genetic changes. As the cancer continues to grow, additional changes will occur even within the same tumor.

The genetic changes that contribute to cancer tend to affect three main types of genes – proto-oncogenes, tumor suppressor genes, and DNA repair genes. All these genes are involved in normal cell growth, maintenance, and division.

Before cancer cells form in tissues of the body, the cells go through abnormal changes called hyperplasia and dysplasia. In hyperplasia, there is an increase in the number of cells in an organ or tissue that appear normal under a microscope. In dysplasia, the cells look abnormal under a microscope but are not cancer. Hyperplasia and dysplasia may or may not become cancer.

A cancer that has spread from the place where it first started to another place in the body is called metastatic cancer .

In metastasis, cancer cells break away from where they first formed (primary cancer), travel through the blood or lymph system, and form new tumors (metastatic tumors) in other parts of the body.

The metastatic tumor is the same type of cancer as the primary tumor. Metastatic tumors can cause severe damage to how the body functions, and most people who die of cancer die of metastatic disease.

Types of Cancer

There are more than 100 types of cancer. Types of cancer are usually named for the organs or tissues where the cancers form. Cancers also may be described by the type of cell that formed them, such as an epithelial cell or a squamous cell. Here are some categories of cancers that begin in specific types of cells:

Melanoma is cancer that begins in cells that become melanocytes, which are specialized cells that make melanin (the pigment that gives skin its color). Most melanomas form on the skin, but melanomas can also form in other pigmented tissues, such as the eye.

Sarcomas are cancers that form in bone and soft tissues, including muscle, fat, blood vessels, lymph vessels, and fibrous tissue (such as tendons and ligaments). Osteosarcoma is the most common cancer of bone.

Lymphoma is cancer that begins in lymphocytes (T cells or B cells). These are disease-fighting white blood cells that are part of the immune system. In lymphoma, abnormal lymphocytes build up in lymph nodes and lymph vessels, as well as in other organs of the body.

Carcinomas are the most common type of cancer. They are formed by epithelial cells, which are the cells that cover the inside and outside surfaces of the body. There are many types of epithelial cells, which often have a column-like shape when viewed under a microscope.

Multiple myeloma is cancer that begins in plasma cells, another type of immune cell. The abnormal plasma cells, called myeloma cells, build up in the bone marrow and form tumors in bones all through the body.

Cancers that begin in the blood-forming tissue of the bone marrow are called leukemia. These cancers do not form solid tumors. Instead, large numbers of abnormal white blood cells build up in the blood and bone marrow, crowding out normal blood cells. The low level of normal blood cells can make it harder for the body to get oxygen to its tissues, control bleeding, or fight infections.

Types of Treatment for Cancer

There are many types of conventional cancer treatment. The types of treatment that you receive will depend on the type of cancer you have and how advanced it is. The main types of cancer treatment include:

  • Surgery
  • Radiation Therapy
  • Chemotherapy
  • Immunotherapy
  • Targeted Therapy
  • Hormone Therapy
  • Stem Cell Transplant
  • Precision Medicine

Radiation Therapy

At high doses, radiation kills cancer cells or slows their growth. Radiation therapy is used to either treat cancer or ease cancer symptoms.

Radiation therapy does not kill cancer cells right away. It takes days or weeks of treatment before cancer cells start to die. Then, cancer cells keep dying for weeks or months after radiation therapy ends.

There are two main types of radiation therapy, External Beam Radiation Therapy and Internal Radiation Therapy.

Internal Radiation Therapy

Internal radiation therapy is a treatment in which a source of radiation is put inside your body. The radiation source can be solid or liquid in the form of seeds, ribbons, or capsules placed in your body in or near the cancer. You receive liquid radiation through an IV line. Liquid radiation travels throughout your body, seeking out and killing cancer cells.

External Beam Radiation Therapy

External beam radiation therapy comes from a machine that aims radiation at your cancer and treats a specific part of your body.

Side Effects

Radiation not only kills or slows the growth of cancer cells, it can also affect nearby healthy cells. Damage to healthy cells can cause side effects. The most common side effect of radiation therapy is fatigue, which is feeling exhausted and worn out. Fatigue can happen all at once or little by little. Healthy cells that are damaged during radiation treatment almost always recover after it is over. But sometimes people may have side effects that are severe or do not improve. Other side effects may show up months or years after radiation therapy is over. Doctors try to protect healthy cells during treatment by using as low a dose of radiation as possible, by spreading out treatment over time, and by aiming radiation at a precise part of your body.


Chemotherapy is used to treat many types of cancer. For some people, chemotherapy may be the only treatment you receive. But most often, you will have chemotherapy and other cancer treatments. The types of treatment that you need depends on the type of cancer you have, if it has spread and where, and if you have other health problems.

When used with other treatments, chemotherapy can:

Make a tumor smaller before surgery or radiation therapy, and destroy cancer cells that may remain after treatment with surgery or radiation therapy. Chemotherapy can also help other treatments work better.

Side Effects

Chemotherapy not only kills fast-growing cancer cells, but also kills or slows the growth of healthy cells that grow and divide quickly. Examples are cells that line your mouth and intestines and those that cause your hair to grow. Damage to healthy cells may cause side effects, such as mouth sores, nausea, and hair loss. Side effects often get better or go away after you have finished chemotherapy. The most common side effect is fatigue, which is feeling exhausted and worn out.


One reason that cancer cells thrive is because they are able to hide from your immune system. Certain immunotherapies can mark cancer cells so it is easier for the immune system to find and destroy them. Other immunotherapies boost your immune system to work better against cancer.

Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. The immune system is made up of white blood cells and organs and tissues of the lymph system. Many different types of immunotherapy are used to treat cancer. They include:

Monoclonal Antibodies

These are drugs that are designed to bind to specific targets in the body and cause an immune response that destroys cancer cells. Other types of monoclonal antibodies can “mark” cancer cells so it is easier for the immune system to find and destroy them. These types of monoclonal antibodies may also be referred to as targeted therapy.

Adoptive Cell Transfer

This is a treatment that attempts to boost the natural ability of your T-cells to fight cancer. T-cells are a type of white blood cell and part of the immune system. Researchers isolate T-cells that are most active against your cancer from the tumor and then grow large batches of these T-cells in the lab and then inject them via a needle in your vein.


These are proteins that are made by your body’s cells. They play important roles in the body’s normal immune responses and also in the immune system’s ability to respond to cancer.

Treatment Vaccines

These work against cancer by boosting your immune system’s response to cancer cells.


This is an immunotherapy that is used to treat bladder cancer. When weakened form of the bacteria that causes tuberculosis is inserted directly into the bladder with a catheter, BCG causes an immune response against cancer cells.

Side Effects

Immunotherapy can cause side effects. The side effects you may have depend on the type of immunotherapy you receive and how your body reacts to it. The most common side effects are skin reactions at the needle site. These side effects include pain, swelling, soreness, redness, rash, fever, chills, nausea, fatigue, etc.

Ionized Calcium Therapy for Cancer

Calcium Ions Turns Apoptosis Back On

Innovative ionized calcium therapy destroys cancer cells by re-activating muted gene responsible for apoptosis or cell self-destruction. In normal cells, P53 gene triggers cell death when a cell is damaged or aging, allowing new healthy cells to replace it.

However, many cancer cells mass produce NF-kB protein which interferes with the function of P53 gene and turns off apoptosis, causing damaged cells to continue dividing and multiplying. NF-kB is produced in cytoplasm, and then translocated into the nucleus and binds to P53 gene, inhibiting its original functions.

Calcium ions, once introduced into cancer cells, inhibits NF-kB’s effect on P53 gene and therefore restores the function of self-destruction. Cancer cells have only 1% of calcium ions of healthy normal cells, linking widespread calcium deficiency in America to rise of occurrence of cancer for further studies.

In the advanced stage of cancer where P53 gene is damaged beyond repair, calcium ions block lactic acid and inhibit the inflow of glucose into the cells, causing cancer to starve to death.

Calcium ions fight cancer in many other way as well. In pancreatic cancer (90%), intestine cancer, lung cancer and thyroid cancer (50%), liver cancer (30%), and leukemia (30%), RAS inhibitor gene mutation in cancer can be found and Ca++ corrects cancer suppressor gene to normal cell.

Also, in brain tumor, intestine cancer, pancreatic cancer, breast cancer, bladder cancer, lung cancer, and more, cyclooxygenase-2 enzyme (COX-2) is responsible for spreading cancer. Calcium ions inhibit this enzyme by making body fluid alkaline. After all, calcium is our body’s natural acid buffer.

Dietary acids affect your body’s buffering capability, which may cause a calcium loss from your bones to counteract the acidity. Acidosis is caused by kidney disease, dehydration, alcohol, high dietary protein and other health problems. Increased cancer risk is also associated with dietary lifestyles that alter systemic acid-base balance over time and lead to a sub-clinical or low-grade state of metabolic acidosis. The relationship between diet and cancer risk prompts questions about the role of acidosis in the initiation and progression of cancer. SAC counteracts acidosis.

Cell Alkaline Theory

In battling cancer, it is important to eliminate the environment that first caused or nurtured cancer cells. Studies have shown that blood oxygen level of patients with cancer is much lower than that of healthy people. Also, a Nobel prize winner (Otto Warburg, 1883-1970) found that depriving a cell 35% of its oxygen for 48 hours made it cancerous.

There is close relationship between lack of both oxygen and calcium in cancer cells because calcium is responsible for delivering oxygen to intercellular space. Therefore, lack of calcium in cancer cells leads to lack of oxygen which leads to highly acidic environment which cancer favors.

Cancer cells are highly acidic, having pH level of about 4.5. Having enough glucose and not enough oxygen to metabolize it, glucose in cancer cells accumulates as lactic acid through anaerobic glycolysis, also known as fermentation, making cancer cells highly acidic.

Lactic acid produced provides cancer with ideal thriving environment in which to grow and to spread. By making intercellular space reach ideal pH by calcium ions, more influx of oxygen with calcium ions will eliminate cancer-thriving environment.

What do I expect from SAC treatment?

SAC rebuilds underlying health while liberating from many symptoms

Diagnosed with disease

Reliable studies link many major degenerative diseases to calcium deficiency. Yet, most people are calcium deficient due to lifestyle and diet.

Calcium deficiency may be the single most underlying condition that makes us susceptible to hypertension, cancer, diabetes, osteoporosis, Alzheimer’s, arthritis, spinal stenosis, bone spurs, insomnia, kidney stones, heart attack, stroke, etc…

6 months

Remission Induction


Calcium deficiency reversed by the flow of calcium ions.

Rapid recovery from symptoms begins and maintained by influx of calcium ions. Patient feels better and symptoms may disappear, but improved condition is only maintained by influx of calcium ions. Symptoms may relapse if the influx of calcium ions stop.

6 - 12 months



SAC intake must continue despite the absense of symptoms until patient’s body fully recovers to maintain his own health.

SAC serves as scaffolding until body rebuilds itself. Patient continues to feel normal but less and less dependent on SAC as his own health slowly catches up.

18+ months



Even after patient’s health is restored, maintenance dosage of SAC is recommended to combat calcium deficiency that started health issues in the first place.

Good health is maintained by healthy lifestyle and boost from SAC.

Sample Clinical Cases

SAC may trigger the increase of cancer markers: As tumors are destroyed by SAC (apoptosis and other anti-cancer effects), marker proteins are dumped into blood vessels and may reflect increased level in blood works. For cancer patients whose health is deteriorating, increasing cancer marker comes with deteriorating blood work. However, patients taking SAC will see improving blood works and feel much better, though often find increased cancer marker, not because the cancer is getting worse but because it is destroyed.

SAC may cause the increase of tumor size: Due to rapid death of cancer cells, tumors are internally filled with fluid and may look bloated and larger. This is not to be mistaken as tumor growth. Tumor density test will reveal decreased tumor density despite the increase of the size. Patients are advised to confirm with tumor density test.

Calcium Ions Assault Cancer Both Within and Without

When popular therapies focus on destroying cancer cells from outside, calcium ion therapy destroys cancer cells both within and without by restoring our body’s natural process for eliminating damaged cells and by eliminating the environment cancer favors.

Pronuvia’s new innovative SAC transport system delivers calcium ions directly into our blood vessels and carries it to every parts of our body affected by cancer, even where chemotherapy has difficulty reaching.

Pronuvia’s SAC Calcium
has passive transport movement and moves calcium ions to blood through linings of our digestive system. Calcium ions are the only physiologically active calcium that reacts with genes, stem cells, hormones, and enzymes, etc.

Regular calcium supplements have active transport movement that can only be absorbed with the help of vitamin D and peptide. Such calcium ends up as protein-bound calcium and is not physiologically active and thus not much useful.

SAC vs Calcium Supplements Copy

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SAC vs Calcium Supplements

Americans today are facing a serious health issue: More than 75% of Americans are calcium deficient, setting ourselves up for a major health breakdown.

The stomach needs a strongly acidic environment for calcium absorption from food or supplements. However, people over the age of 60 produce only 1/4 of the stomach acid they did when they were 20, leading to poor absorption of calcium.

Most of what is absorbed doesn’t end up in the bones, due to lack of exercise and a more sedentary life style.

Even with a plethora of calcium supplements sold in America, incidences of osteoporosis are still on the increase. Why?

There are many problems with traditional calcium supplements since their calcium absorption rates are usually too low to be of use. Sources – such as from coral, plants or algae, may vary in quality, but the problem is that absorbed calcium enters our blood vessels as inactive protein-bound calcium which our body cannot utilize directly to build up bones.

Protein calcium is only utilized after extensive exercise which most elderly Americans do not engage in. Even worse, high calcium intake in this protein-bound form develops unpleasant effects such as acid rebound and mineral imbalance, to name a few.

For these reasons, many trained medical professionals discourage the use of calcium supplements.

Building the Bone Density

Almost all your body’s calcium is stored in bone, but the tiny amount that circulates in your bloodstream is disproportionately vital to normal physiology.

About half of this circulating calcium (50%) is “ionized”, which means it carries electrical charges.

Ionized calcium (Ca2+) is the only physiologically active form that can be recognized by our body and absorbed in our bones.

Ionized calcium in the blood is so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in the concentration of ionized calcium in the blood triggers the bone-building process to take excess calcium into bones.

Utilizing this process is by far the most effective and safe way to build bone density since it follows the body’s natural bone building mechanism.*

Triggering Bone Formulation

When the calcium ion concentration rises even slightly, the thyroid gland immediately increases the secretion of calcitonin into the blood, which removes calcium from the blood plasma and deposits it as new bone.

The above process is both natural and safe, but there has simply been no way to add ionized calcium into our blood serum directly to initiate the bone formation process… until today.

The revolutionary SAC Formulation Technology has made possible what other calcium supplements and prescription drugs could not achieve. Supporting and sustaining the natural bone-building process through the flash of calcium ions.*

High-Dose Vitamin D and Calcium Attenuates Bone Loss with Antiretroviral Therapy Initiation: A Prospective, Randomized Placebo-Controlled Trial for Bone Health in HIV-Infected Individuals

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High-Dose Vitamin D and Calcium Attenuates Bone Loss with Antiretroviral Therapy Initiation: A Prospective, Randomized Placebo-Controlled Trial for Bone Health in HIV-Infected Individuals

Edgar Turner Overton, MD, Ellen S. Chan, MSc, Todd T. Brown, MD, PhD, Pablo Tebas, MD, Grace A. McComsey, MD, Kathleen M. Melbourne, PharmD, Andrew Napoli, PhD, William Royce Hardin, BS, Heather J. Ribaudo, PhD, and Michael T. Yin, MD MS

Antiretroviral therapy (ART) has transformed HIV infection from a terminal disease to a manageable chronic illness. While incidence of AIDS-defining conditions has declined, other comorbidities have increased (1), including osteoporosis and fragility fractures (2-7). Both viral and host factors likely contribute to bone loss and fracture risk: HIV infection mediated by certain viral proteins, HIV-associated inflammation, lifestyle and behavioral factors, underlying genetic predisposition, comorbidities, and ART (8-14).

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Calcium Signalling and Calcium Transport in Bone Disease

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Calcium Signalling and Calcium Transport in Bone Disease

H.C. Blair, P.H. Schlesinger, Christopher L.-H. Huang, and M. Zaidi

Calcium transport and calcium signalling mechanisms in bone cells have, in many cases, been discovered by study of diseases with disordered bone metabolism. Calcium matrix deposition is driven primarily by phosphate production, and disorders in bone deposition include abnormalities in membrane phosphate transport such as in chondrocalcinosis, and defects in phosphate-producing enzymes such as in hypophosphatasia. Matrix removal is driven by acidification, which dissolves the mineral. Disorders in calcium removal from bone matrix by osteoclasts cause osteopetrosis. On the other hand, although bone is central to management of extracellular calcium, bone is not a major calcium sensing organ, although calcium sensing proteins are expressed in both osteoblasts and osteoclasts. Intracellular calcium signals are involved in secondary control including cellular motility and survival, but the relationship of these findings to specific diseases is not clear. Intracellular calcium signals may regulate the balance of cell survival versus proliferation or anabolic functional response as part of signalling cascades that integrate the response to primary signals via cell stretch, estrogen, tyrosine kinase, and tumor necrosis factor receptors

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SAC and Bone Health

By | SAC, Uncategorized

SAC Therapy and Bone Health

SAC Increases Bone Turnover to Repair and Rebuild Bone Matrix

SAC in a

SAC (Sigma Antibonding Calcium Carbonate) is the only true ionic calcium delivery system that provides calcium in free ionic state, which is the only physiologically active form of calcium in our body. Normally, calcium from diet and supplements enters our body in the protein-bound form and therefore, cannot trigger the same physiological responses as SAC. Resolving calcium deficiency better than protein-bound calcium, SAC triggers ionic-calcium-sensitive physiological responses that counteract the root cause of diseases and brings natural healing reactions of our body from cellular to the systemic level.

Age Related
Bone Loss


  • Sedentary Lifestyle
  • Lower Sex Hormones
  • Lower Osteocalcin
  • Lower hGH
  • Lower Calmodulin
  • Menopause
  • Poor Absorption of Calcium

Osteoporosis Is Inevitable for Most.
It is Just a Matter of When

Bone is living, growing tissue. Throughout life, our bodies are breaking down old bone cells and rebuilding new bones in a continuous cycle (bone remodeling). This process is necessary to repair damages caused by daily stress on our bones.

When we are younger, we gain more bone than lose. However, after about age 40, this balance is typically reversed, with bone loss occurring at a much faster rate than is replaceable, leaving our bones brittle and leading to osteoporosis with increased risks of fracture, particularly of the hip, spine, wrist and shoulder.

Osteoblasts and osteoclasts are types of cells the human body uses to repair broken bones. Osteoclasts break down old bone tissue allowing osteoblasts to replace it with new material. Together, these cells facilitate bone mending and bone growth. However, as we age osteoblast slows down and bone mineral density continues to decrease, making our bones more susceptible to fracture.

Osteoporosis weakens bones

Losing more than 25% of bone mass is enough for a clinical diagnosis of osteoporosis. In the US, 1/3 of women and 1/4 of men have the disease, with the figure increasing each year. What may be the cause of all this?  Stress, sedentary lifestyle, poor diet, environmental toxins, illnesses, and hormonal change that is a part of aging process.

Serious Side Effects of Prescription Drugs

Physicians typically recommend prescription medications for the treatment of osteoporosis, but these drugs are notorious for their dangerous side effects. These drugs are designed to “increase” bone density by retaining dead bone mass through the inhibition of osteoclasts, the cells that are responsible for natural bone resorption, which provides calcium for our body’s needs. Our body takes calcium from bones – even at the risk of bone fractures, because of calcium’s urgent and crucial role in healthy cell replication, neurotransmission, heart functions, and endocrine functions.


Blood in stool and urine, fatigue, stomach ulcers, nausea, hair loss, blurred vision, constipation, joint pain, cramps, swelling, vomiting, chest pain, blood clots, depression, pain swallowing, dizziness, unusual bone fracture, severe bone, joint, muscle pain, weakens immune system, serious infections, etc. (From medications such as Forteo, Prolia, Fosamax, Actonel, Boniva, Evista)

Disrupting essential bone metabolism may lead to serious health hazards.

This is why there are so many reports that osteoporosis drugs actually make bones more brittle and that people who are treated with these drugs tend to suffer more bone fractures.  Disrupting natural bone remodeling and bone metabolism has serious health risks that maybe more devastating.

Understanding the Risks of Prescription Drugs

Efforts to prevent fracture risk should not interfere with calcium homeostasis that affects functions of trillions of cells

Anti-resorptive Drugs

Drugs that slow bone loss

Antiresorptive therapies are used to increase bone strength by slowing or stopping osteoclast in individuals with osteoporosis and include five principal classes of agents: bisphosphonates, estrogens, selective estrogen receptor modulators (SERMs), calcitonin and monoclonal antibodies such as denosumab.

Bisphosphonates are the most commonly prescribed antiresorptive medications and remain first-line treatment for osteoporosis. Bisphosphonates are adsorbed into the mineralized surface of bone and are internalized by osteoclasts, interfering with biochemical processes involved in bone resorption; they also induce apoptosis of osteoclasts.

Denosumab, the first biologic introduced for osteoporosis treatment, is a fully human monoclonal RANKL antibody, and by binding to RANKL, it prevents the binding of RANKL to RANK; this leads to inhibition of osteoclast activation and function.

When osteoclast led bone resorption is interrupted, bone is not properly repaired. Also, bone resorption is a natural biological process that provides crucial ionic calcium needed for trillions cells to work properly.  Disrupting this process just to keep calcium in the bones is not a viable solution.

Anabolic Drugs

Drugs that increase the rate of bone formation

Trailing the development of antiresorptives for osteoporosis is the development of anabolic agents designed to increase bone mineral density (BMD) by stimulating bone formation, osteoblast. Sodium fluoride was a promising anabolic agent for the treatment of postmenopausal osteoporosis, but it was found to increase the risk of nonvertebral fractures despite dramatic increases in BMD and is not approved by FDA in the USA. GH (growth hormone) has also been the object of interest as an anabolic agent for the skeleton. PTH (parathyroid hormone), long known to have anabolic potential was “rediscovered” about 15 yrs ago, but the bone-building effect was not very impressive (only 6% increase) and also came with many side effects.

The statins, cornerstones of lipid-lowering therapy, have also recently been revisited as potentially important skeletal anabolic agents, but we are too familiar with the side effects of statins.

Serious Side Effects of Prescription Drugs

Physicians typically recommend prescription medications for the treatment of osteoporosis, but these drugs are notorious for their dangerous side effects. These drugs are designed to “increase” bone density by retaining dead bone mass through the inhibition of osteoclasts, the cells that are responsible for natural bone resorption, which provides calcium for our body’s needs. Our body takes calcium from bones – even at the risk of bone fractures, because of calcium’s urgent and crucial role in healthy cell replication, neurotransmission, heart functions, and endocrine functions.


Blood in stool and urine, fatigue, stomach ulcers, nausea, hair loss, blurred vision, constipation, joint pain, cramps, swelling, vomiting, chest pain, blood clots, depression, pain swallowing, dizziness, unusual bone fracture, severe bone, joint, muscle pain, weakens immune system, serious infections, etc. (From medications such as Forteo, Prolia, Fosamax, Actonel, Boniva, Evista)

SAC Triggers Bone Repair & Rebuilding

SAC is the world’s first calcium-ion-delivery-system, which safely and effectively elevates the level of calcium-ion concentration in our blood. By utilizing a very weak chemical bonding, namely sigma antibonding, to calcium carbonate molecules, Calcium & Bone Health Institute of Canada (CBHI) invented new calcium carbonate, which maintains loosely held calcium ion to its carbonate group.

Because of the weak chemical bonding of SAC, calcium ion is easily detached and passively absorbed into our system through stomach lining as ions via diffusion and osmotic pressure, not requiring digestion, vitamin D, nor peptides for absorption.  This is called passive transport.

Because of our body’s natural sensitivity to fluctuations of serum plasma ionic calcium level, a minimal elevation of ionic calcium concentration achieved by SAC can trigger hormonal responses, such as the release of TSH and calcitonin to trigger bone-building osteoblasts. SAC therapy utilizes ionic calcium as a signaling agent to trigger our body’s natural responses to increase bone turnover rate in repairing and building healthy bones.  SAC’s healing pathway is genuinely unique without side effects experienced in prescription drugs.

The 4 Functions of SAC Calcium

SAC as Hormone Regulator

Bone metabolism is controlled by the interaction of a number of hormones.

Hormonal imbalance can wreak havoc on bone metabolism. SAC helps triggering hormones to maintain bone metabolic balance, by signaling pituitary hormones to trigger the release of thyroid and parathyroid hormones.

SAC as Calcium Navigator

Inactive calcium molecules such as protein-bound calcium do not know where to go.

SAC navigates calcium to reach its ultimate destination – the bone. SAC calcium will not be deposited in the wrong places such as the kidneys or blood vessels.

SAC as Calcium Activator

About 50% of calcium in our blood is inactive.

SAC’s ionization process activates inactive calcium molecules to be used in bone building by stimulating the secretion of thyroid hormone (TH), which is responsible for depositing minerals in our bones.

SAC as Bone Mineral Builder

Without any side effects, SAC calcium considerably aids in the prevention and treatment of osteoporosis, thereby reducing fracture risks by significantly improving bone mineral density.

Within a relatively shorter period of time, SAC helps to deposit other essential minerals from one’s diet into the bone along with calcium for healthier bones.

SAC Therapy Builds Bones Naturally & Effectively

Physiological Effects of SAC

After intake, SAC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.

While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking SAC is experienced, which is both healthy and normal, indicating that SAC is working.


A long term, follow up study done in Denmark for 35,000 people revealed that the people with strong bones in their 50’s lived 11.6 years longer.
YET, in Canada, 49% of infants are born with calcium deficiency. Only 70% recover after breastfeeding. Calcium deficiency during pregnancy and infancy leads to serious health issues.

Bone Loss Leads to 150+ Degenerative Diseases

Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates not only a higher risk of fracture but also a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.

Promising Animal Clinical Trials

Calcium ions in the blood are so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in the concentration of ionized calcium in the blood triggers the bone building process to take excess calcium into bones. Utilizing this process is by far the most effective and safe way to support strong bones since it follows the body’s natural bone building mechanism. This amazing effect of SAC was observed in this animal clinical trial through the bone break test where SAC ‘treated’ bone displayed almost 100x bone building power compared to regular calcium carbonate.

Importance of SAC therapy goes beyond the stronger bone-building.  Although most of our body’s calcium is stored in bone, the tiny amount that circulates in your bloodstream is disproportionately vital to good health. About half of this circulating serum calcium (50%) is “ionized”, which means it carries electrical charges and this calcium ions (Ca2+) are the only physiologically active form that can be recognized by our body and responsible for numerous functions of our body such as the firing of muscle and nerve cells, promoting blood clotting, preventing the depletion of bone mass, securing proper cellular functions by preserving calcium signaling, etc.  As we age, this vital ionic calcium homeostasis is disrupted as our bone breaks down and calcifies trillions of cells.  SAC therapy can restore this fragile calcium homeostasis and gives our body a chance to fight back the onset of 150+ degenerative diseases  that are thought to be caused by calcium displacement.

Osteoporosis Reversed under SAC Therapy

(Lab Anim Res 2011: 27(4), 301-307, 2011)

Sham (Control)
0.2276 ± 0.011 a
OVX (Osteoporosis)
0.1965 ± 0.012 b
0.2276 ± 0.012 a
  • Control: sham operation
  • OVX: no treatment after ovariectomy
  • OVX+SAC: SAC treatment after ovariectomy.

The effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats are studied. The study revealed that the induced osteoporosis was completely reversed with SAC therapy. Osteocalcin, estradiol, eosinophil, CTx and BMD level were elevated with SAC, indicating that optimal bone health is indeed restored.

Values are mean ± SD for 5 rats. Means with different superscript letters are significantly different at p<0.05 by Duncan’s multiple range tests.

Before & After Bone Density Trial Results

Over 90% of Volunteers at CBHI Experienced Significant Increase in BMD

"I have taken MegaGen since I was diagnosed with severe osteoporosis with T-score of -3.7. After taking 17 bottles of Megagen, my bone density is back to the normal range. Incredible!!"

M. S. PARK – Age 55, Male

Human Bone Density Clinical Case under SAC

(CBHI Canada Conducted BMD Increase Trial for +1000 Patients under SAC Therapy.)

CBHI (Calcium & Bone Health Institute of Canada) utilized FDA approved ultrasound bone densitometer by BeamMed in measuring and comparing BMD data of more than a thousand patients.  Over 90% of the patients experienced increased bone density.

Fracture Healing Effects of SAC Therapy

Steroid Induced Osteoporosis, auto fracture (Male, 52, Indonesia)

Dosage: MaraGen 2x /day for first 2 months and then only 1x. Able to walk normally again.

Decalcification Effects of SAC Therapy

Removing Calcification from Cellular to Systemic Level is a Key to Recovery

Conditions Commonly Treated with SAC Therapy

Cellular Recovery Helps to Restore Mitochondrial Function & Reduce Oxidative Stress

  • Autoimmune disease (Lupus, Vitiligo, Hashimoto’s, Crohn’s, Celiac disease, eczema, MS, rheumatoid, etc.)
  • Lyme disease, HIV, Shingles and other viral infections
  • Parkinson’s, ALS, Alzheimer’s and
    other neurodegenerative diseases
  • Arthritis, Gout, CPPD, Inflammations
  • Mitochondrial Disease
  • Cancer (carcinoma, sarcoma,
    lymphoma, leukemia, multiple
  • Arrhythmia, Heart palpitation, Mitral Valve Prolapse,
  • Diabetes, Metabolic Syndrome
  • Thrombosis, Hemolytic Anemia
  • Autism Spectrum Disorder,
  • ADHD, Epilepsy
  • Asthma, COPD
  • Glaucoma, Cataract, Intermittent Exotropia, Retinal Vein Occlusion
  • Menier’s Disease, Aurora Migraine
    Disease, Tinnitus, Vertigo
  • Osteoporosis, Bone Necrosis
  • Chromosome 8 syndrome
  • Chronic Kidney Disease
  • Gum disease, Loose teeth
  • Calcification (joints and tissues),
    Calcific tendonitis, Fibrosis, Kidney
    and Gall Bladder Stones
  • Dysmenorrhea, infertility