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Monthly Archives

March 2020

Calcium wave signaling in cancer cells

By | Cancer

Calcium wave signaling in cancer cells

JAI PARKASHa and KAMLESH ASOTRA

Ca2+ functions as an important signaling messenger right from beginning of the life to final moment of the end of the life. Ca2+ is needed at several steps of the cell cycle such as early G1, at the G1/S, and G2/M transitions. The Ca2+ signals in the form of time-dependent changes in intracellular Ca2+ concentrations, [Ca2+]i, are presented as brief spikes organized into regenerative Ca2+ waves. Ca2+-mediated signaling pathways have also been shown to play important roles in carcinogenesis such as transformation of normal cells to cancerous cells, tumor formation and growth, invasion, angiogenesis and metastasis. Since the global Ca2+ oscillations arise from Ca2+ waves initiated locally, it results in stochastic oscillations because although each cell has many IP3Rs and Ca2+ ions, the law of large numbers does not apply to the initiating event which is restricted to very few IP3Rs due to steep Ca2+ concentration gradients. The specific Ca2+ signaling information is likely to be encoded in a calcium code as the amplitude, duration, frequency, waveform or timing of Ca2+ oscillations and decoded again at a later stage. Since Ca2+ channels or pumps involved in regulating Ca2+ signaling pathways show altered expression in cancer, one can target these Ca2+ channels and pumps as therapeutic options to decrease proliferation of cancer cells and to promote their apoptosis. These studies can provide novel insights into alterations in Ca2+ wave patterns in carcinogenesis and lead to development of newer technologies based on Ca2+ waves for the diagnosis and therapy of cancer.

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SAC Therapy Dosing Protocol (Book)

By | books, SAC

SAC Therapy Dosing Protocol (Book)

Version 1 (2020), Pronuvia

Pronuvia’s SAC therapy utilizes the world’s first calcium-ion-delivery-system called Sigma Anti-Bonding Molecule Calcium Carbonate (SAC-CaCO3), invented by CBHI, a research institute based in BC, Canada.

SAC therapy employs ionic calcium supplementation to successfully elevate the level of physiologically active plasma ionic calcium, triggering our body’s natural functions to build strong bones and re-establish healthy calcium homeostasis. Appropriating influx and efflux of calcium ion modifies mitochondrial functions, improves oxidative stress, and normalizes cellular calcium signaling, which is the key to treating chronic degenerative diseases.

By providing calcium in ionic form, which is the only physiologically active form of calcium in our body, SAC therapy addresses ionic calcium deficiency better than protein-bound calcium supplied through diet and popular calcium supplements available in the market today.

This dosage protocol guideline provides participating physicians with suggestions on how Pronuvia’s SAC-applied products can be utilized effectively in treating communicable and degenerative diseases. By eliciting calcium-sensitive physiological responses that counteract the root cause of diseases, SAC therapy is recommended as a part of a more comprehensive treatment plan. Ionic calcium treatment is still evolving and is undergoing clinical evaluations by participating researchers and doctors.  Pronuvia appreciates many participating physicians for providing inputs in fine-tuning the dosage protocol.

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Introducing SAC Therapy (Book)

By | books, SAC

Introducing SAC Therapy (Book)

Pronuvia

SAC (Sigma Antibonding Calcium Carbonate) is the only true ionic calcium delivery system that provides calcium in free ionic state, which is the only physiologically active form of calcium in our body. Normally, calcium from diet and supplements enters our body in the protein-bound form and therefore, cannot trigger the same physiological responses as SAC. Resolving calcium deficiency better than protein-bound calcium, SAC triggers ionic-calcium-sensitive physiological responses that counteract the root cause of diseases and brings natural healing reactions of our body from cellular to the systemic level.

The purpose of this booklet is to introduce the underlying technology of SAC and the principles behind the new and safe therapy based on SAC technology and to invite interested physicians to partake in our global clinical trial program for their consenting patients. SAC ionic calcium therapy is also recommended as a part of a more comprehensive treatment plan of participating physicians in treating infectious and degenerative diseases.

SAC ionic calcium therapy utilizes SAC-infused products from Pronuvia and is gaining more recognition as the therapy undergoes a decade-long clinical evaluation by participating researchers and doctors.

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