ResourcesSAC SAC vs Calcium Supplements Americans today are facing a serious health issue: More than 75% of Americans are calcium…pronuviaMarch 1, 2018
ResourcesSAC Bone Density Clinical Results How the Measurement is Taken The following clinical results are typical of patients taking SAC…pronuviaMarch 1, 2018
SACUncategorized SAC and Osteoporosis Bone is living, growing tissue. Throughout life, our bodies are breaking down old bone cells…pronuviaFebruary 15, 2018
Cancer Tumour suppression by p53: a role for the DNA damage response? Loss of p53 function occurs during the development of most, if not all, tumour types.…pronuviaMay 1, 2018
Cancer Where cancer meets calcium — p53 crosstalk with EF-hands S100B, an EF-hand Ca2+-binding protein, grasps the C-terminus of the tumor suppressor p53 and inhibits…pronuviaMay 1, 2018
Cancer The 1993 Walter Hubert Lecture: The role of the p53 tumour-suppressor gene in tumorigenesis The p53 tumour-suppress or gene is mutated in 60% of human tumours, and the product…pronuviaMay 1, 2018
Cancer The effect of concurrent radiation and calcium in two cancer cell lines Calcium is an important ubiquitous second messenger regarding the maintenance of cellular homeostasis, and is…pronuviaMay 1, 2018
Cancer Examining the relationship between diet-induced acidosis and cancer Increased cancer risk is associated with select dietary factors. Dietary lifestyles can alter systemic acid-base…pronuviaMay 1, 2018
Cancer Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells Killing cancer cells by cytotoxic T lymphocytes (CTL) and by natural killer (NK) cells is…pronuviaMay 1, 2018
Cancer Calcium homeostasis in cancer: A focus on senescence Senescence is one of the primary responses to the activation of oncoproteins or down-regulation of…pronuviaMay 1, 2018
Cancer Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite? The common preference of cancers for lactic acid-generating metabolic energy pathways has led to proposals…pronuviaMay 1, 2018
Cancer Dairy products, calcium, and prostate cancer risk in the Physicians’ Health Study Background: A high calcium intake, mainly from dairy products, may increase prostate cancer risk by…pronuviaMay 1, 2018
Cancer Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case–control study in the San Francisco Bay area Copy Objective The aim of this study was to evaluate a com- plex association among intake…pronuviaMay 1, 2018
Cancer Direct Therapeutic Applications of Calcium Electroporation to Effectively Induce Tumor Necrosis Electroporation of cells with short, high-voltage pulses causes a transient permeabilization of cell membranes that…pronuviaMay 1, 2018
Cancer Dose-Dependent ATP Depletion and Cancer Cell Death following Calcium Electroporation, Relative Effect of Calcium Concentration and Electric Field Strength Electroporation, a method for increasing the permeability of membranes to ions and small molecules, is…pronuviaMay 1, 2018
Cancer Calcium, Magnesium, and Colorectal Cancer High calcium consumption may confer a reduced risk of colorectal cancer.1,2 Dai and colleagues recently…pronuviaMay 1, 2018
Cancer Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming…pronuviaMay 1, 2018
Cancer Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B S100B is an EF-hand containing calcium-binding protein of the S100 protein family that exerts its…pronuviaMay 1, 2018
Cancer Calcium electroporation in three cell lines: a comparison of bleomycin and calcium, calcium compounds, and pulsing conditions Background: Electroporation with calcium (calcium electroporation) can induce ATP depletion-associated cellu- lar death. In the…pronuviaMay 1, 2018
Cancer Calcium, Calcineurin and the Control of Transcription Calcineurin (PP2B), a serine threonine kinase controlled by cellular calcium, was originally identified by Klee…pronuviaMay 1, 2018
Cancer Regulation of calcium signaling in lung cancer Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous…pronuviaMarch 5, 2018
DentalResources Calcium Ion for Dentistry Edentulous (Bone Loss) Periodontitis Periodontal Ligament / LooseTeeth Gum Tissue / Gingivitis Bone Graft Assist…pronuviaMay 20, 2018
Dental Effects of varied ionic calcium and phosphate on the proliferation, osteogenic differentiation and mineralization of human periodontal ligament cells in vitro A number of bone-filling materials containing calcium (Ca2+) and phosphate (P) ions have been used…pronuviaMay 1, 2018
Diabetes Serum Calcium Levels In Type 2 Diabetes Mellitus Hyperglycemia in Diabetes Mellitus is known to have its effect on almost all body system…pronuviaMay 1, 2018
DNA Repair Switching p53 states by calcium: dynamics and interaction of stress systems The integration of calcium and a p53–Mdm2 oscillator model is studied using a deterministic as…pronuviaMay 2, 2018
DNA Repair Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor S100B protein is elevated in the brains of patients with early stages of Alzheimer’s disease…pronuviaMay 2, 2018
DNA Repair Possible role of NF-kB and p53 in the glutamate-induced pro-apoptotic neuronal pathway Apoptosis is now recognized as an important component in many progressive and acute neurodegenerative diseases.…pronuviaMay 2, 2018
DNA Repair PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kB, MAPkinase and p53 pathways The phosphoinositide 3-kinase (PI3-kinase) signalling pathway plays a key role in the regulation of cell…pronuviaMay 2, 2018
DNA Repair p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner The tumor suppressor p53 is a key protein in preventing cell transformation and tumor progression.…pronuviaMay 2, 2018
DNA Repair p53: Good Cop/Bad Cop Activation of the p53 transcription factor in response to a variety of cellular stresses, including…pronuviaMay 2, 2018
DNA Repair Transcriptional Cross Talk between NF- B and p53 Many cellular stimuli result in the induction of both the tumor suppressor p53 and NF-…pronuviaMay 2, 2018
DNA Repair Bendable Electro-chemical Lactate Sensor Printed with Silver Nano- particles Here we report a exible amperometric lactate biosensor using silver nanoparticle based conductive electrode. Mechanically…pronuviaMay 2, 2018
DNA Repair Concerted Regulation of Wild-Type p53 Nuclear Accumulation and Activation by S100B and Calcium-Dependent Protein Kinase C The calcium ionophore ionomycin cooperates with the S100B protein to rescue a p53-dependent G1 check-…pronuviaMay 2, 2018
DNA Repair Glucose Metabolism, Lactate, and Ammonia Production by the Human Placenta In Vitro Fifteen human placentas were obtained at term. Placental frag- ments were incubated in a bicarbonate-buffered…pronuviaMay 2, 2018
DNA Repair p53 Dependent DNA repair and apoptosis respond differently to high and low-dose ultraviolet radiation Copy pronuviaMay 1, 2018
DNA Repair The p53 response to DNA damage The p53 tumour suppressor protein is a highly potent transcription factor which, under normal circumstances,…pronuviaMay 1, 2018
DNA Repair p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/or gadd45 Genes Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair (NER), the…pronuviaMay 1, 2018
DNA Repair Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development XRCC4 is a non-homologous end-joining protein employed in DNA double strand break repair and in…pronuviaMay 1, 2018
DNA Repair The role of calcium in human lymphocyte DNA repair ability DNA repair ability is reduced in a variety of pathologic conditions. In addition, in some…pronuviaMay 1, 2018
Lyme New insights into Lyme disease Lyme borreliosis is transmitted through the bite of a tick that is infected by the…pronuviaMay 1, 2018
Mitochondria The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis While many studies have focused on cytochrome c release from mitochondria, little attention has been…pronuviaMay 2, 2018
Mitochondria Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming In recent years, mitochondria have emerged as important targets of agonist-dependent increases in cytosolic Ca2+…pronuviaMay 2, 2018
Mitochondria Mitochondria Modify Exercise-Induced Development of Stem Cell-Derived Neurons in the Adult Brain Neural stem cells in the adult mammalian hippocampus continuously generate new functional neurons, which modify…pronuviaMay 2, 2018
Mitochondria Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes We have used digital fluorescence imaging techniques to explore the interplay between mitochondrial Ca2+ uptake…pronuviaMay 2, 2018
Mitochondria Mitochondria and Ca2+ in cell physiology and pathophysiology There is now a consensus that mitochondria take up and accumulate Ca2+ during physiological c…pronuviaMay 2, 2018
Mitochondria Cytochrome c Association with the Inner Mitochondrial Membrane Is Impaired in the CNS of G93A-SOD1 Mice A “gain-of-function” toxic property of mutant Cu–Zn superoxide dismutase 1 (SOD1) is involved in the…pronuviaMay 2, 2018
Mitochondria Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit itochondria are dynamic organelles in cells. The control of mitochondrial motility by signaling mechanisms and…pronuviaMay 2, 2018
Mitochondria Cmc1p Is a Conserved Mitochondrial Twin CX9C Protein Involved in Cytochrome c Oxidase Biogenesis Copper is an essential cofactor of two mitochondrial enzymes: cytochrome c oxidase (COX) and Cu-Zn…pronuviaMay 2, 2018
Mitochondria The molecular era of the mitochondrial calcium uniporter The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its biophysical properties and…pronuviaMay 1, 2018
Osteoporosis Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC)…pronuviaMay 2, 2018
Osteoporosis Role of the calcium-sensing receptor in parathyroid gland physiology The calcium-sensing receptor (CaSR) represents the molecular mechanism by which parathyroid cells detect changes in…pronuviaMay 2, 2018
Stem Cells The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis The pathways and identification of cell injury and cell death are of key importance to…pronuviaMay 1, 2018
Stem Cells Stem Cells and Calcium Signaling The increasing interest in stem cell research is linked to the promise of developing treatments…pronuviaMay 1, 2018
Stem Cells Effects of Repetitive lonomycin Treatment on In Vitro Development of Bovine Somatic Cell Nuclear Transfer Embryos To artificially activate embryos in somatic cell nuclear transfer (SCNT), chemical treatment with ionomycin has…pronuviaMay 1, 2018
Stem Cells Role of NF-kB in p53-mediated programmed cell death The tumour suppressor p53 inhibits cell growth through activation of cell-cycle arrest and apoptosis1, and…pronuviaMay 1, 2018
Stem Cells Developmental Cell intracellular Ca2+ transients. While basal mitochondrial Ca2+ (Ca2+ mito) is needed to maintain organellar physiology,…pronuviaMay 1, 2018
Stem Cells Mechanisms of p53-dependent apoptosis Cellular stresses, such as growth factor deprivation, DNA damage or oncogene expression, lead to stabilization…pronuviaMay 1, 2018
Stem Cells Effects of varied ionic calcium and phosphate on the proliferation, osteogenic differentiation and mineralization of human periodontal ligament cells in vitro Hyaline cartilage is an avascular, aneural and alymphatic tissue covering the ends of long bones…pronuviaMay 1, 2018
Stem Cells Biology of signalling receptors in human articular chondrocytes Hyaline cartilage is an avascular, aneural and alymphatic tissue covering the ends of long bones…pronuviaMay 1, 2018
Stem Cells Calcium signalling in chondrogenesis: Implications for cartilage repair Undifferentiated mesenchymal stem cells (MSCs) represent an important source for cell-based tissue regeneration techniques that…pronuviaMay 1, 2018
Stem Cells Purinergic signalling-evoked intracellular Ca2+ concentration changes in the regulation of chondrogenesis and skeletal muscle formation It is now widely recognised that changes of the intracellular calcium concentration have deep impact…pronuviaMay 1, 2018
Stem Cells The role of PML in the control of apoptotic cell fate: a new key player at ER–mitochondria sites The development of malignant tumors results from deregulated proliferation or an inability of cells to…pronuviaMay 1, 2018
Stem Cells Activated AKT regulates NF-jB activation, p53 inhibition and cell survival in HTLV-1-transformed cells AKT activation enhances resistance to apoptosis and induces cell survival signaling through multiple downstream pathways.…pronuviaMay 1, 2018
Stem Cells Insufficient Intracellular Calcium Ion Causes Mitochondrial Dysfunction and Inactivation of Mesenchymal Stem Cells: Sigma Anti-Bonding Molecule Calcium Carbonate (SAC), the New Technology to Treat Aging-Related Chronic Degenerative Diseases It is prevalently known that tumour cells prefer inefficient cellular glycolysis, but no one has…pronuviaMay 1, 2018