Americans today are facing a serious health issue: More than 75% of Americans are calcium…
pronuviaMarch 1, 2018
Resources
Bone is living, growing tissue. Throughout life, our bodies are breaking down old bone cells…
pronuviaFebruary 15, 2018
Loss of p53 function occurs during the development of most, if not all, tumour types.…
pronuviaMay 1, 2018
S100B, an EF-hand Ca2+-binding protein, grasps the C-terminus of the tumor suppressor p53 and inhibits…
pronuviaMay 1, 2018
The p53 tumour-suppress or gene is mutated in 60% of human tumours, and the product…
pronuviaMay 1, 2018
Calcium is an important ubiquitous second messenger regarding the maintenance of cellular homeostasis, and is…
pronuviaMay 1, 2018
Increased cancer risk is associated with select dietary factors. Dietary lifestyles can alter systemic acid-base…
pronuviaMay 1, 2018
Killing cancer cells by cytotoxic T lymphocytes (CTL) and by natural killer (NK) cells is…
pronuviaMay 1, 2018
Senescence is one of the primary responses to the activation of oncoproteins or down-regulation of…
pronuviaMay 1, 2018
The common preference of cancers for lactic acid-generating metabolic energy pathways has led to proposals…
pronuviaMay 1, 2018
Background: A high calcium intake, mainly from dairy products, may increase prostate cancer risk by…
pronuviaMay 1, 2018
Objective The aim of this study was to evaluate a com- plex association among intake…
pronuviaMay 1, 2018
Electroporation of cells with short, high-voltage pulses causes a transient permeabilization of cell membranes that…
pronuviaMay 1, 2018
Electroporation, a method for increasing the permeability of membranes to ions and small molecules, is…
pronuviaMay 1, 2018
High calcium consumption may confer a reduced risk of colorectal cancer.1,2 Dai and colleagues recently…
pronuviaMay 1, 2018
Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming…
pronuviaMay 1, 2018
S100B is an EF-hand containing calcium-binding protein of the S100 protein family that exerts its…
pronuviaMay 1, 2018
Background: Electroporation with calcium (calcium electroporation) can induce ATP depletion-associated cellu- lar death. In the…
pronuviaMay 1, 2018
Calcineurin (PP2B), a serine threonine kinase controlled by cellular calcium, was originally identified by Klee…
pronuviaMay 1, 2018
Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous…
pronuviaMarch 5, 2018
Hyperglycemia in Diabetes Mellitus is known to have its effect on almost all body system…
pronuviaMay 1, 2018
The integration of calcium and a p53–Mdm2 oscillator model is studied using a deterministic as…
pronuviaMay 2, 2018
S100B protein is elevated in the brains of patients with early stages of Alzheimer’s disease…
pronuviaMay 2, 2018
Apoptosis is now recognized as an important component in many progressive and acute neurodegenerative diseases.…
pronuviaMay 2, 2018
The phosphoinositide 3-kinase (PI3-kinase) signalling pathway plays a key role in the regulation of cell…
pronuviaMay 2, 2018
The tumor suppressor p53 is a key protein in preventing cell transformation and tumor progression.…
pronuviaMay 2, 2018
Activation of the p53 transcription factor in response to a variety of cellular stresses, including…
pronuviaMay 2, 2018
Many cellular stimuli result in the induction of both the tumor suppressor p53 and NF-…
pronuviaMay 2, 2018
Here we report a exible amperometric lactate biosensor using silver nanoparticle based conductive electrode. Mechanically…
pronuviaMay 2, 2018
The calcium ionophore ionomycin cooperates with the S100B protein to rescue a p53-dependent G1 check-…
pronuviaMay 2, 2018
Fifteen human placentas were obtained at term. Placental frag- ments were incubated in a bicarbonate-buffered…
pronuviaMay 2, 2018
The p53 tumour suppressor protein is a highly potent transcription factor which, under normal circumstances,…
pronuviaMay 1, 2018
Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair (NER), the…
pronuviaMay 1, 2018
XRCC4 is a non-homologous end-joining protein employed in DNA double strand break repair and in…
pronuviaMay 1, 2018
DNA repair ability is reduced in a variety of pathologic conditions. In addition, in some…
pronuviaMay 1, 2018
Lyme borreliosis is transmitted through the bite of a tick that is infected by the…
pronuviaMay 1, 2018
While many studies have focused on cytochrome c release from mitochondria, little attention has been…
pronuviaMay 2, 2018
In recent years, mitochondria have emerged as important targets of agonist-dependent increases in cytosolic Ca2+…
pronuviaMay 2, 2018
Neural stem cells in the adult mammalian hippocampus continuously generate new functional neurons, which modify…
pronuviaMay 2, 2018
We have used digital fluorescence imaging techniques to explore the interplay between mitochondrial Ca2+ uptake…
pronuviaMay 2, 2018
There is now a consensus that mitochondria take up and accumulate Ca2+ during physiological c…
pronuviaMay 2, 2018
A “gain-of-function” toxic property of mutant Cu–Zn superoxide dismutase 1 (SOD1) is involved in the…
pronuviaMay 2, 2018
itochondria are dynamic organelles in cells. The control of mitochondrial motility by signaling mechanisms and…
pronuviaMay 2, 2018
Copper is an essential cofactor of two mitochondrial enzymes: cytochrome c oxidase (COX) and Cu-Zn…
pronuviaMay 2, 2018
The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its biophysical properties and…
pronuviaMay 1, 2018
The pathways and identification of cell injury and cell death are of key importance to…
pronuviaMay 1, 2018
The increasing interest in stem cell research is linked to the promise of developing treatments…
pronuviaMay 1, 2018
To artificially activate embryos in somatic cell nuclear transfer (SCNT), chemical treatment with ionomycin has…
pronuviaMay 1, 2018
The tumour suppressor p53 inhibits cell growth through activation of cell-cycle arrest and apoptosis1, and…
pronuviaMay 1, 2018
intracellular Ca2+ transients. While basal mitochondrial Ca2+ (Ca2+ mito) is needed to maintain organellar physiology,…
pronuviaMay 1, 2018
Cellular stresses, such as growth factor deprivation, DNA damage or oncogene expression, lead to stabilization…
pronuviaMay 1, 2018
Hyaline cartilage is an avascular, aneural and alymphatic tissue covering the ends of long bones…
pronuviaMay 1, 2018
Hyaline cartilage is an avascular, aneural and alymphatic tissue covering the ends of long bones…
pronuviaMay 1, 2018
Undifferentiated mesenchymal stem cells (MSCs) represent an important source for cell-based tissue regeneration techniques that…
pronuviaMay 1, 2018
It is now widely recognised that changes of the intracellular calcium concentration have deep impact…
pronuviaMay 1, 2018
The development of malignant tumors results from deregulated proliferation or an inability of cells to…
pronuviaMay 1, 2018
AKT activation enhances resistance to apoptosis and induces cell survival signaling through multiple downstream pathways.…
pronuviaMay 1, 2018
It is prevalently known that tumour cells prefer inefficient cellular glycolysis, but no one has…
pronuviaMay 1, 2018
Did you know that about 147 diseases are related to calcium?
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