NF-κB, inflammation and metabolic disease
Rebecca G. Baker, Matthew S. Hayden, and Sankar Ghosh*
Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia
University, New York, NY 10032
Metabolic disorders including obesity, type 2 diabetes and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.