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SAC & Dental Health

By | Dental, Resources, SAC

SAC Therapy and Dental Health

SAC Stimulates Stem Cells to Repair and Rebuild Jaw Bones

SAC in a
Nutshell

SAC (Sigma Antibonding Calcium Carbonate) is the only true ionic calcium delivery system that provides calcium in free ionic state, which is the only physiologically active form of calcium in our body. Normally, calcium from diet and supplements enters our body in the protein-bound form and therefore, cannot trigger the same physiological responses as SAC. Resolving calcium deficiency better than protein-bound calcium, SAC triggers ionic-calcium-sensitive physiological responses that counteract the root cause of diseases and brings natural healing reactions of our body from cellular to the systemic level.

Edentulism -
Age Related
Jaw Bone Loss

Dental health deteriorates with aging and affects our health dramatically and is closely related to the skeletal bone loss (osteoporosis) that comes with hormonal changes and life style changes associated with aging.  As jaw bones shrink, our teeth lose its footing to stay strong.  Edentulism in the elderly population around the world is between 11% and 44%, inversely increasing to socioeconomic status.

The use of implants is considered to be one of the most popular alternatives for its high predictability, durability, and functionality to rehabilitate patients aesthetically and functionally. However, the success of the procedure depends heavily on the supporting dental bone quality. The loss of alveolar bone due to periodontitis is also a signicant concern for all age groups, as it supports not only possible implants, but also natural teeth.  Conclusively, it is the quality and the strength of jaw bones that ultimately determines the success of all  dental procedures.

Periodic increase of calcium ions in our system achieved by SAC Ionic Calcium Therapy, however, can trigger cascade of hormonal responses from pituiatary to thyroid glands that trigger and regulate both TH and PTH to raise bone mineral density (BMD) naturally without side effects. SAC delivers a safe level of calcium ions which in turn regulates bone turnover rates (absorption and resorption rates) to build healthy bones including deteriorating alveola bones of maxilla and mandible.

Age Related
Bone Loss

CAUSES OF AGE RELATED BONE LOSS:

  • Sedentary Lifestyle
  • Lower Sex Hormones
  • Lower Osteocalcin
  • Lower hGH
  • Lower Calmodulin
  • Menopause
  • Poor Absorption of Calcium

Osteoporosis Is Inevitable for Most.
It is Just a Matter of When

Bone is living, growing tissue. Throughout life, our bodies are breaking down old bone cells and rebuilding new bones in a continuous cycle (bone remodeling). This process is necessary to repair damages caused by daily stress on our bones.

When we are younger, we gain more bone than lose. However, after about age 40, this balance is typically reversed, with bone loss occurring at a much faster rate than is replaceable, leaving our bones brittle and leading to osteoporosis with increased risks of fracture, particularly of the hip, spine, wrist and shoulder.

Osteoblasts and osteoclasts are types of cells the human body uses to repair broken bones. Osteoclasts break down old bone tissue allowing osteoblasts to replace it with new material. Together, these cells facilitate bone mending and bone growth. However, as we age osteoblast slows down and bone mineral density continues to decrease, making our bones more susceptible to fracture.

Osteoporosis weakens bones

Losing more than 25% of bone mass is enough for a clinical diagnosis of osteoporosis. In the US, 1/3 of women and 1/4 of men have the disease, with the figure increasing each year. What may be the cause of all this?  Stress, sedentary lifestyle, poor diet, environmental toxins, illnesses, and hormonal change that is a part of aging process.

Stimulating hPDLCs Stem Cells for Repairing and Rebuilding

Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration by dierentiating into either cementoblasts to synthesize root cementum or osteoblasts to synthesize alveolar bone.

Many researches investigated the effects of extracellular calcium on cell proliferation and osteogenic differentiation of human periodontal ligament cells (hPDLCs). In the human PDLSC line they examined, calcium treatment increased the expression of genes of bone-related molecules such as BMP-2, OCN, OPN, and RUNX2, and also resulted in mineralization. These genes are found to facilitate the periodontal ligament cells and regulated by RUNX2.

SAC releases physiologically active calcium ions to stimulate stem cells to restore the physiological function of teeth by rebuilding periodontal supporting tissues including alveolar bone, gingiva, periodontal ligaments (PDL), and the cementum.

Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration by dierentiating into either cementoblasts to synthesize root cementum or osteoblasts to synthesize alveolar bone.

Many researches investigated the effects of extracellular calcium on cell proliferation and osteogenic differentiation of human periodontal ligament cells (hPDLCs). In the human PDLSC line they examined, calcium treatment increased the expression of genes of bone-related molecules such as BMP-2, OCN, OPN, and RUNX2, and also resulted in mineralization. These genes are found to facilitate the periodontal ligament cells and regulated by RUNX2.

SAC releases physiologically active calcium ions to stimulate stem cells to restore the physiological function of teeth by rebuilding periodontal supporting tissues including alveolar bone, gingiva, periodontal ligaments (PDL), and the cementum.

SAC Restores Calcium Homeostasis for Optimum Stem Cell Functions

SAC Ionic Calcium Therapy for Dentistry

Synthetic bone replacement is used to fill and restore alveolar bone, and a number of bone-lling materials containing calcium (Ca2+) and phosphate (P) ions have been also used in the repair of periodontal bone defects. However, the effects that local release of Ca2+ and P ions have on biological reactions are not fully understood. To make bone graft materials work better, targeting the underlying condition of calcium and hormone imbalance is essential.  SAC delivers physiologically active calcium ions that trigger the systemic regulation of hormones and restores calcium homeostasis which revives the core metabolism.

Application of SAC for Dentistry

  • Edentulous (Bone Loss)
  • Periodontitis / Gingivitis /Gum Tissue
  • Periodontal Ligament / LooseTeeth
  • Bone Graft Assist / Implant Osseointegration

Sample Clinical Case of SAC Therapy in Dentistry

Generally lower jaw is harder to build than upper jaw bone. SAC calcium therefore promotes cementogenesis for the formation of cementum.

The x-ray images of a 58 year old Asian male who conducted molar tooth extraction show signicant dental bone growth after treating with SAC for 7 months without any co-treatments

Effects of Ionic Calcium for Dentistry

  • Helps restore and maintain your oral health
  • Creates strong jaw bones to support the teeth
  • Great for patients undergoing dental implants
  • Significantly promotes cementogenesis,the formation of cementum

Periodontal gum line recedes with age as the aveolar bone underneath is lost to edentulism.  When strong osteoblast in initiated with SAC Ionic Therapy, aveolar bone in strengthened again to support loose teeth.  Restored calcium homeostasis triggers dormant hPDLC stem cells to proliferate and repair the damaged ligaments.

“My dentist extracted my molar tooth with cavity 6 months ago. He recommended that I do an implant after bone graft. I then remembered hearing about DentiGen and told him that I would come back after increasing my jaw bone density. The dentist said that there is simply no way to increase jaw bone density and that he would eat his hat if my bone density increased. For a few months I took DentiGen faithfully and visited the dentist. He could not believe what he saw in xrays! He did not end up eating his hat but confirmed that now implant is doable due to increased jaw bone density. Wow!”

Soonok Chung – Age 47, Female

SAC Triggers Bone Repair & Rebuilding

SAC is the world’s first calcium-ion-delivery-system, which safely and effectively elevates the level of calcium-ion concentration in our blood. By utilizing a very weak chemical bonding, namely sigma antibonding, to calcium carbonate molecules, Calcium & Bone Health Institute of Canada (CBHI) invented new calcium carbonate, which maintains loosely held calcium ion to its carbonate group.

Because of the weak chemical bonding of SAC, calcium ion is easily detached and passively absorbed into our system through stomach lining as ions via diffusion and osmotic pressure, not requiring digestion, vitamin D, nor peptides for absorption.  This is called passive transport.

Because of our body’s natural sensitivity to fluctuations of serum plasma ionic calcium level, a minimal elevation of ionic calcium concentration achieved by SAC can trigger hormonal responses, such as the release of TSH and calcitonin to trigger bone-building osteoblasts. SAC therapy utilizes ionic calcium as a signaling agent to trigger our body’s natural responses to increase bone turnover rate in repairing and building healthy bones.  SAC’s healing pathway is genuinely unique without side effects experienced in prescription drugs.

The 4 Functions of SAC Calcium

SAC as Hormone Regulator

Bone metabolism is controlled by the interaction of a number of hormones.

Hormonal imbalance can wreak havoc on bone metabolism. SAC helps triggering hormones to maintain bone metabolic balance, by signaling pituitary hormones to trigger the release of thyroid and parathyroid hormones.

SAC as Calcium Navigator

Inactive calcium molecules such as protein-bound calcium do not know where to go.

SAC navigates calcium to reach its ultimate destination – the bone. SAC calcium will not be deposited in the wrong places such as the kidneys or blood vessels.

SAC as Calcium Activator

About 50% of calcium in our blood is inactive.

SAC’s ionization process activates inactive calcium molecules to be used in bone building by stimulating the secretion of thyroid hormone (TH), which is responsible for depositing minerals in our bones.

SAC as Bone Mineral Builder

Without any side effects, SAC calcium considerably aids in the prevention and treatment of osteoporosis, thereby reducing fracture risks by significantly improving bone mineral density.

Within a relatively shorter period of time, SAC helps to deposit other essential minerals from one’s diet into the bone along with calcium for healthier bones.

SAC Therapy Builds Bones Naturally & Effectively

Physiological Effects of SAC

After intake, SAC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.

While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking SAC is experienced, which is both healthy and normal, indicating that SAC is working.

STRONGER BONES LEAD TO A HEALTHIER LIFE

A long term, follow up study done in Denmark for 35,000 people revealed that the people with strong bones in their 50’s lived 11.6 years longer.
YET, in Canada, 49% of infants are born with calcium deficiency. Only 70% recover after breastfeeding. Calcium deficiency during pregnancy and infancy leads to serious health issues.

Bone Loss Leads to 150+ Degenerative Diseases

Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates not only a higher risk of fracture but also a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.

Promising Animal Clinical Trials

Calcium ions in the blood are so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in the concentration of ionized calcium in the blood triggers the bone building process to take excess calcium into bones. Utilizing this process is by far the most effective and safe way to support strong bones since it follows the body’s natural bone building mechanism. This amazing effect of SAC was observed in this animal clinical trial through the bone break test where SAC ‘treated’ bone displayed almost 100x bone building power compared to regular calcium carbonate.

Importance of SAC therapy goes beyond the stronger bone-building.  Although most of our body’s calcium is stored in bone, the tiny amount that circulates in your bloodstream is disproportionately vital to good health. About half of this circulating serum calcium (50%) is “ionized”, which means it carries electrical charges and this calcium ions (Ca2+) are the only physiologically active form that can be recognized by our body and responsible for numerous functions of our body such as the firing of muscle and nerve cells, promoting blood clotting, preventing the depletion of bone mass, securing proper cellular functions by preserving calcium signaling, etc.  As we age, this vital ionic calcium homeostasis is disrupted as our bone breaks down and calcifies trillions of cells.  SAC therapy can restore this fragile calcium homeostasis and gives our body a chance to fight back the onset of 150+ degenerative diseases  that are thought to be caused by calcium displacement.

Osteoporosis Reversed under SAC Therapy

(Lab Anim Res 2011: 27(4), 301-307, 2011)

Group
BMD
Sham (Control)
0.2276 ± 0.011 a
OVX (Osteoporosis)
0.1965 ± 0.012 b
OVX + SAC
0.2276 ± 0.012 a
  • Control: sham operation
  • OVX: no treatment after ovariectomy
  • OVX+SAC: SAC treatment after ovariectomy.

The effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats are studied. The study revealed that the induced osteoporosis was completely reversed with SAC therapy. Osteocalcin, estradiol, eosinophil, CTx and BMD level were elevated with SAC, indicating that optimal bone health is indeed restored.

Values are mean ± SD for 5 rats. Means with different superscript letters are significantly different at p<0.05 by Duncan’s multiple range tests.

Before & After Bone Density Trial Results

Over 90% of Volunteers at CBHI Experienced Significant Increase in BMD

"I have taken MegaGen since I was diagnosed with severe osteoporosis with T-score of -3.7. After taking 17 bottles of Megagen, my bone density is back to the normal range. Incredible!!"

M. S. PARK – Age 55, Male

Human Bone Density Clinical Case under SAC

(CBHI Canada Conducted BMD Increase Trial for +1000 Patients under SAC Therapy.)

CBHI (Calcium & Bone Health Institute of Canada) utilized FDA approved ultrasound bone densitometer by BeamMed in measuring and comparing BMD data of more than a thousand patients.  Over 90% of the patients experienced increased bone density.

Fracture Healing Effects of SAC Therapy

Steroid Induced Osteoporosis, auto fracture (Male, 52, Indonesia)

Dosage: MaraGen 2x /day for first 2 months and then only 1x. Able to walk normally again.

Decalcification Effects of SAC Therapy

Removing Calcification from Cellular to Systemic Level is a Key to Recovery

Conditions Commonly Treated with SAC Therapy

Cellular Recovery Helps to Restore Mitochondrial Function & Reduce Oxidative Stress

  • Autoimmune disease (Lupus, Vitiligo, Hashimoto’s, Crohn’s, Celiac disease, eczema, MS, rheumatoid, etc.)
  • Lyme disease, HIV, Shingles and other viral infections
  • Parkinson’s, ALS, Alzheimer’s and
    other neurodegenerative diseases
  • Arthritis, Gout, CPPD, Inflammations
  • Mitochondrial Disease
  • Cancer (carcinoma, sarcoma,
    lymphoma, leukemia, multiple
    myeloma)
  • Arrhythmia, Heart palpitation, Mitral Valve Prolapse,
  • Diabetes, Metabolic Syndrome
  • Thrombosis, Hemolytic Anemia
  • Autism Spectrum Disorder,
  • ADHD, Epilepsy
  • Asthma, COPD
  • Glaucoma, Cataract, Intermittent Exotropia, Retinal Vein Occlusion
  • Menier’s Disease, Aurora Migraine
    Disease, Tinnitus, Vertigo
  • Osteoporosis, Bone Necrosis
  • Chromosome 8 syndrome
  • Chronic Kidney Disease
  • Gum disease, Loose teeth
  • Calcification (joints and tissues),
    Calcific tendonitis, Fibrosis, Kidney
    and Gall Bladder Stones
  • Dysmenorrhea, infertility

Effects of varied ionic calcium and phosphate on the proliferation, osteogenic differentiation and mineralization of human periodontal ligament cells in vitro

By | Dental

Effects of varied ionic calcium and phosphate on the proliferation, osteogenic differentiation and mineralization of human periodontal ligament cells in vitro

An S, Ling J, Gao Y, Xiao Y.

A number of bone-filling materials containing calcium (Ca2+) and phosphate (P) ions have been used in the repair of periodontal bone defects; however, the effects that local release of Ca2+ and P ions has on biological reactions are not fully understood. In this study, we investigated the effects of various levels of Ca2+ and P ions on the proliferation, osteogenic differentiation and mineralization of human periodontal ligament cells (hPDLCs).

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